Generation of red blood cells from induced pluripotent stem cells
Naomi Gunawardena,
Stella T. Chou
Abstract:Purpose of review
Human induced pluripotent stem cells (iPSCs) are an attractive source to generate in-vitro-derived blood for use as transfusable and reagent red cells. We review recent advancements in the field and the remaining limitations for clinical use.
Recent findings
For iPSC-derived red blood cell (RBC) generation, recent work has optimized culture conditions to omit feeder cells, enhance red cell maturation, and produce cells that mimic fetal… Show more
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