Generation of reactive oxygen species under singlet oxygen photosensitivity by chlorophyll and its analogs

Лобанов, А. В.; Kobzev, G. I.; Davydov, K. S.; Komissarov, G. G.

doi:10.1134/s1990793114030221

Cited by 4 publications

(5 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The flow process mimics the biosynthetic pathway, using 5,10,15,20‐tetraphenylporphyrin or 9,10‐dicyanoanthracene (DCA) as the photosensitizer instead of chlorophyll . While abundant in nature, chlorophyll has rarely been used for synthetic transformations .…”

Section: Figurementioning

confidence: 99%

“…Thef low process mimics the biosynthetic pathway,u sing 5,10,15,20-tetraphenylporphyrin or 9,10-dicyanoanthracene (DCA) as the photosensitizer instead of chlorophyll. [18][19][20][21][22] While abundant in nature,c hlorophyll has rarely been used for synthetic transformations. [23,24] Ac rude mixture of artemisinin, DHAA, as well as chlorophyll derivatives extracted from A. annua leaves can be fed directly into af low photooxidation reactor in the presence of acid to convert DHAA into artemisinin.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Literally Green Chemical Synthesis of Artemisinin from Plant Extracts

Triemer

Gilmore

et al. 2018

Angew Chem Int Ed

View full text Add to dashboard Cite

Active pharmaceutical ingredients are either extracted from biological sources-where they are synthesized in complex, dynamic environments-or prepared in stepwise chemical syntheses by reacting pure reagents and catalysts under controlled conditions. A combination of these two approaches, where plant extracts containing reagents and catalysts are utilized in intensified chemical syntheses, creates expedient and sustainable processes. We illustrate this principle by reacting crude plant extract, oxygen, acid, and light to produce artemisinin, a key active pharmaceutical ingredient of the most powerful antimalarial drugs. The traditionally discarded extract of Artemisia annua plants contains dihydroartemisinic acid-the final biosynthetic precursor-as well as chlorophyll, which acts as a photosensitizer. Efficient irradiation with visible light in a continuous-flow setup produces artemisinin in high yield, and the artificial biosynthetic process outperforms syntheses with pure reagents.

show abstract

Section: Figurementioning

confidence: 99%

mentioning

confidence: 99%

Literally Green Chemical Synthesis of Artemisinin from Plant Extracts

Triemer

Gilmore

et al. 2018

Angew Chem Int Ed

View full text Add to dashboard Cite

show abstract

“…Der kontinuierliche Prozess imitiert die Biosynthese, wobei anstatt von Chlorophyll 5,10,15,20‐Tetraphenylporphyrin oder 9,10‐Dicyananthracen als Photosensibilisatoren eingesetzt werden. Obwohl Chlorophyll allgegenwärtig in der Natur ist, wurde es bisher nur selten für Synthesezwecke verwendet .…”

Section: Figureunclassified

“…Die intensivierte Prozessführung in kontinuierlichen Schlauchreaktoren mit geringem Durchmesser ermçglicht hierbei eine effizientere Beleuchtung der Reaktionslçsung und einen schnelleren Stofftransport zwischen der Flüssigund Gasphase als in Batch-Reaktoren. [16,17] Der kontinuierliche Prozess imitiert die Biosynthese, wobei anstatt von Chlorophyll [18][19][20][21][22] 5,10,15,20-Tetraphenylporphyrin oder 9,10-Dicyananthracen als Photosensibilisatoren eingesetzt werden. Obwohl Chlorophyll allgegenwärtig in der Natur ist, wurde es bisher nur selten fürSynthesezwecke verwendet.…”

Section: Angewandte Chemieunclassified

“…[16,17] The flow process mimics the biosynthetic pathway, using 5,10,15,20-tetraphenylporphyrin or 9,10-dicyanoanthracene (DCA) as a photosensitizer instead of chlorophyll. [18][19][20][21][22] Although plentiful in nature, chlorophyll has rarely been used for synthetic transformations. [23,24] A crude mixture of artemisinin, DHAA, as well as chlorophyll derivatives extracted from A. annua leaves (Table S1 in SI).…”

mentioning

confidence: 99%

See 1 more Smart Citation

Wirklich grüne Synthese von Artemisinin aus Pflanzenextrakt

Triemer

Gilmore

et al. 2018

Angewandte Chemie

View full text Add to dashboard Cite

Active pharmaceutical ingredients are either extracted from biological sourceswhere they are synthesized in complex, dynamic environmentsor prepared via step-wise chemical syntheses by reacting pure reagents and catalysts under controlled conditions. A combination of these two approaches, where plant extracts containing reagents and catalysts are utilized in intensified chemical syntheses, creates expedient and sustainable processes. We illustrate the principle by reacting crude plant extract, oxygen, acid, and light to produce artemisinin, a key active pharmaceutical ingredient of the most powerful anti-malaria drugs. The traditionally discarded extract of Artemisia annua plants contains dihydroartemisinic acid-the final biosynthetic precursor-as well as chlorophyll, which acts as a photosensitizer. Efficient illumination with visible light in a continuous flow setup produces artemisinin in high yield, and the artificial biosynthetic process outperforms syntheses using pure reagents.

show abstract

Water restriction scenarios and their effects on traits in potato with different degrees of drought tolerance

Ramírez

Qin

et al. 2019

Scientia Horticulturae

View full text Add to dashboard Cite

Generation of reactive oxygen species under singlet oxygen photosensitivity by chlorophyll and its analogs

Cited by 4 publications

References 12 publications

Literally Green Chemical Synthesis of Artemisinin from Plant Extracts

Literally Green Chemical Synthesis of Artemisinin from Plant Extracts

Wirklich grüne Synthese von Artemisinin aus Pflanzenextrakt

Water restriction scenarios and their effects on traits in potato with different degrees of drought tolerance

Contact Info

Product

Resources

About