Generation of Platelet-Activating Factor (PAF)-Like Phospholipids in Blood Circulation under Elevated Oxidative Stress: Its Pathological Significance on Atherosclerosi
Abstract:Summary Oxidative modification of low-density lipoprotein (LDL) is known to be a critical factor for pathogenesis of atherosclerosis. Several newly generated lipid components in the oxidatively modified LDL (oxLDL) have been shown to exert undesirable effects on various vascular cells. In particular, phosphatidylcholine (PC) having an oxidatively shortened fatty acyl group with a methyl, hydroxyl, oxo or carboxyl terminal attained interest, since they mimic diverse effects of platelet-activating factor (PAF), … Show more
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