2021
DOI: 10.1002/cti2.1313
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Generation of plasma cells and CD27IgD B cells during hantavirus infection is associated with distinct pathological findings

Abstract: B-cell responses during hantavirus infectionPF Kerkman et al.

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Cited by 9 publications
(5 citation statements)
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References 59 publications
(134 reference statements)
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“…We then assessed the distribution of switched memory B cells (CD19 + CD20 + CD27 + IgD - ), unswitched memory B cells (CD19 + CD20 + CD27 + IgD + ), naïve B cells (CD19 + CD20 + CD27 - IgD + ), and double negative (DN) B cells (CD19 + CD20 + CD27 - IgD - ). The frequencies of these populations in the control group were similar to previously reported findings ( 19 ), whereas the MS patients had reconstituted a predominantly naïve repertoire during RTX treatment interruption ( Figure 4C ).…”
Section: Resultssupporting
confidence: 89%
See 1 more Smart Citation
“…We then assessed the distribution of switched memory B cells (CD19 + CD20 + CD27 + IgD - ), unswitched memory B cells (CD19 + CD20 + CD27 + IgD + ), naïve B cells (CD19 + CD20 + CD27 - IgD + ), and double negative (DN) B cells (CD19 + CD20 + CD27 - IgD - ). The frequencies of these populations in the control group were similar to previously reported findings ( 19 ), whereas the MS patients had reconstituted a predominantly naïve repertoire during RTX treatment interruption ( Figure 4C ).…”
Section: Resultssupporting
confidence: 89%
“…A similar difference was noted for S-specific unswitched memory B cells and we could also demonstrate that patients had a higher frequency of antigen-specific DN B cells than healthy controls at four weeks post a second BNT162b2 dose ( Figure 4D ). We have previously shown that B cells downregulate the complement regulatory protein DAF upon BCR engagement, and that DN B cells in circulation may reflect ongoing B cell responses in lymphoid organs ( 19 , 20 ). We found that patients had increased frequencies of DAF - cells in all B cell populations except for switched memory B cells one week after the second dose ( Figure 4E ).…”
Section: Resultsmentioning
confidence: 99%
“…The cells showed reduced BCR signaling and antibody production upon stimulation, leading to the thought that the B cells were anergic or exhausted (39). Other infections where B cells with a CD21 lo CD27 lo IgD − phenotype are observed to expand are hepatitis C virus (HCV) (42,43), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (44)(45)(46), hantavirus infection (47) tuberculosis (48), and possibly others.…”
Section: Alternative B Cell Differentiation In Disease and Vaccinationmentioning
confidence: 99%
“…Peripheral NK cells show signs of strong activation and proliferation in the acute phase of HFRS [ 31 33 ]. B and T cells are highly expanded in the circulation of HFRS and HPS patients, with concomitant elevated levels of CD8 + T cells in the respiratory airways [ 24 , 34 37 ]. Mucosa-associated invariant T (MAIT) cells were recently shown to be reduced, but highly activated, in circulation during PUUV-caused HFRS [ 27 ].…”
Section: Introductionmentioning
confidence: 99%