2019
DOI: 10.1016/j.envint.2019.105140
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Generation of nano- and micro-sized organic pollutant emulsions in simulated road runoff

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Cited by 8 publications
(5 citation statements)
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“…The enhanced C max and AUC values could be the effect of the enhanced SMEDDS formulation increasing the solubility and/or dissolving rate of PGL. Additionally, excipients such as Tween® 80 and Transcutol HP included in the SMEDDS formulation have been reported to inhibit P-gp and CYP 450 ( Al-Kandari et al, 2020 , Markiewicz et al, 2019 ) and thus promote intestinal absorption of PGL. The pharmacokinetic profile confirms the in vitro release results showing that pioglitazone of the suspension was primarily absorbed from the stomach which can be interpreted by the higher solubility of PGL in an acidic pH and the absence of overexpression of P-gp in the stomach.…”
Section: Discussionmentioning
confidence: 99%
“…The enhanced C max and AUC values could be the effect of the enhanced SMEDDS formulation increasing the solubility and/or dissolving rate of PGL. Additionally, excipients such as Tween® 80 and Transcutol HP included in the SMEDDS formulation have been reported to inhibit P-gp and CYP 450 ( Al-Kandari et al, 2020 , Markiewicz et al, 2019 ) and thus promote intestinal absorption of PGL. The pharmacokinetic profile confirms the in vitro release results showing that pioglitazone of the suspension was primarily absorbed from the stomach which can be interpreted by the higher solubility of PGL in an acidic pH and the absence of overexpression of P-gp in the stomach.…”
Section: Discussionmentioning
confidence: 99%
“…Analysis of variance was conducted using a Zetasizer NANO S laser particle size analyzer (Malvern Instruments, UK). The measuring range of the device is from 0.3 nm to 10,000 nm [18].…”
Section: The Study Materials and Methodsmentioning
confidence: 99%
“…A similar laboratory study to evaluate the efficiency of PH removal by rain gardens under controlled laboratory conditions was conducted by the authors of [16]. The experiment was carried out on two prototypes of modified rain garden structures with a soil substrate based on a specially developed mineral-organic mixture and a drainage channel.…”
Section: Analysis Of the Leachate From The Experimental Columnsmentioning
confidence: 99%
“…Some types of OPs (PHs, phthalates, and polycyclic aromatic hydrocarbons (PAHs)) are hydrophobic, which allows them to be removed from the aqueous phase by simple methods, such as particle sedimentation [15]. There are also hydrophilic-hydrophobic compounds, such as diesel hydrocarbons, alkylphenols (APs) and their ethoxylates (APEOs), diesel fuel with APs and APEOs, phthalates, and used engine oil components, which can form nano-and micro-dispersed emulsions in rainwater [16]. Therefore, when choosing a stormwater treatment method, it is also advisable to take into account that such waters contain colloids, truly dissolved components, and emulsions of OPs.…”
Section: Introductionmentioning
confidence: 99%
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