Generation of microdamage around endosseous implants

Warreth, Abdulhadi; Polyzois, Ioannis; Lee, Clive T.; Claffey, Noel

doi:10.1111/j.1600-0501.2009.01808.x

Cited by 23 publications

(32 citation statements)

References 45 publications

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“…Although microdamage accumulation and increased bone remodeling are clearly evidenced in peri-screw bone [1], [2], [13], [17], [19], [26], [27], [28], [29], little is known about the repair mode for microdamage induced by screw insertion. Like fatigue damage, both linear cracks and diffuse damage were visible in peri-screw bone [1], [2], [28].…”

Section: Discussionmentioning

confidence: 99%

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Repair of Microdamage in Osteonal Cortical Bone Adjacent to Bone Screw

Wang

Deng

et al. 2014

PLoS ONE

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Up to date, little is known about the repair mode of microdamage in osteonal cortical bone resulting from bone screw implantation. In this study, self-tapping titanium cortical bone screws were inserted into the tibial diaphyses of 24 adult male rabbits. The animals were sacrificed at 1 day, 2 weeks, 1 month and 2 months after surgery. Histomorphometric measurement and confocal microscopy were performed on basic fuchsin stained bone sections to examine the morphological characteristics of microdamage, bone resorption activity and spatial relationship between microdamage and bone resorption. Diffuse and linear cracks were coexisted in peri-screw bone. Intracortical bone resorption was significantly increased 2 weeks after screw installation and reach to the maximum at 1 month. There was no significant difference in bone resorption between 1-month and 2-months groups. Microdamage was significantly decreased within 1 month after surgery. Bone resorption was predisposed to occur in the region of <100 µm from the bone-screw interface, where had extensive diffuse damage mixed with linear cracks. Different patterns of resorption cavities appeared in peri-screw bone. These data suggest that 1) the complex microdamage composed of diffuse damage and linear cracks is a strong stimulator for initiating targeted bone remodeling; 2) bone resorption activities taking place on the surfaces of differently oriented Haversian and Volkmann canals work in a team for the repair of extensive microdamage; 3) targeted bone remodeling is a short-term reaction to microdamage and thereby it may not be able to remove all microdamage resulting from bone screw insertion.

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Section: Discussionmentioning

confidence: 99%

“…Like fatigue damage, both linear cracks and diffuse damage were visible in peri-screw bone [1], [2], [28]. It has been reported that diffuse damage is much less effective for triggering bone resorption than linear cracks, suggesting that the responses to diffuse damage and linear cracks are different [21], [22].…”

Section: Discussionmentioning

confidence: 99%

Repair of Microdamage in Osteonal Cortical Bone Adjacent to Bone Screw

Wang

Deng

et al. 2014

PLoS ONE

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“…Excessive tension may cause irreversible damage to the periimplant bone tissue (6). Conversely, too low tension may unsatisfactorily stimulate the bone repair process (4).…”

Section: Introductionmentioning

confidence: 99%

“…Clinical studies have demonstrated a close relationship between initial stabilization and the success of an osseointegrated implant (11)(12)(13), which can be measured by the insertion torque during implant placement (12). The insertion torque must exceed 30 Ncm to obtain predictable success rates (12,14), aiming at avoiding implant micromovement and consequent connective tissue formation (6,13). However, an excessively high insertion torque, above 50 Ncm (15), can occur during dense bone implant placement (12,16,17), resulting in the transmission of high compressive stresses to the adjacent bone, in addition to compromising osseointegration success (3).…”

Section: Introductionmentioning

confidence: 99%

Influence of high insertion torque on implant placement: an anisotropic bone stress analysis

et al. 2010

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The aim of this study was to evaluate the influence of the high values of insertion torques on the stress and strain distribution in cortical and cancellous bones. Based on tomography imaging, a representative mathematical model of a partial maxilla was built using Mimics 11.11 and Solid Works 2010 softwares. Six models were built and each of them received an implant with one of the following insertion torques: 30, 40, 50, 60, 70 or 80 Ncm on the external hexagon. The cortical and cancellous bones were considered anisotropic. The bone/implant interface was considered perfectly bonded. The numerical analysis was carried out using Ansys Workbench 10.0. The convergence of analysis (6%) drove the mesh refinement. Maximum principal stress (σ max ) and maximum principal strain (ε max ) were obtained for cortical and cancellous bones around to implant. Pearson's correlation test was used to determine the correlation between insertion torque and stress concentration in the periimplant bone tissue, considering the significance level at 5%. The increase in the insertion torque generated an increase in the σ max and ε max values for cortical and cancellous bone. The σ max was smaller for the cancellous bone, with greater stress variation among the insertion torques. The ε max was higher in the cancellous bone in comparison to the cortical bone. According to the methodology used and the limits of this study, it can be concluded that higher insertion torques increased tensile and compressive stress concentrations in the periimplant bone tissue.

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“…Because the time of implant insertion is too short for bone to relax, the bone tissue might experience inelastic phenomena with the possibility of permanent elastic strains in periimplant bone (Duyck et al 2010;Natali et al 2009). Research has also supported the hypothesis that implant insertion may cause initiation of microcracks in peri-implant bone (Huja et al 1999;Warreth et al 2009). …”

Section: Discussionmentioning

confidence: 87%

Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains: a validation in rat tibiae

Torcasio

Zhang

Oosterwyck

et al. 2011

Biomech Model Mechanobiol

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Although research has been addressed at investigating the effect of specific loading regimes on bone response around the implant, a precise quantitative understanding of the local mechanical response close to the implant site is still lacking. This study was aimed at validating micro-CT-based finite element (µFE) models to assess tissue strains after implant placement in a rat tibia. Small implants were inserted at the medio-proximal site of 8 rat tibiae. The limbs were subjected to axial compression loading; strain close to the implant was measured by means of strain gauges. Specimen-specific µFE models were created and analyzed. For each specimen, 4 different models were created corresponding to different representations of the bone-implant interface: bone and implant were assumed fully osseointegrated (A); a low stiffness interface zone was assumed with thickness of 40 µm (B), 80 µm (C), and 160 µm (D). In all cases, measured and computational strains correlated highly (R 2 = 0.95, 0.92, 0.93, and 0.95 in A, B, C, and D, respectively). The averaged calculated strains were 1.69, 1.34, and 1.15 times higher than the measured strains for A, B, and C, respectively, and lower than the experimental strains for D (factor = 0.91). In conclusion, we demonstrated that specimen-specific FE analyses provide accurate estimates of peri-implant bone strains in the rat tibia loading model. Fur-

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Generation of microdamage around endosseous implants

Abstract: The results of this study suggest that most of the microcracks were generated by the osteotomy preparation and the other modalities did not appear to have any major additional effects.

Cited by 23 publications

References 45 publications

Repair of Microdamage in Osteonal Cortical Bone Adjacent to Bone Screw

Repair of Microdamage in Osteonal Cortical Bone Adjacent to Bone Screw

Influence of high insertion torque on implant placement: an anisotropic bone stress analysis

Use of micro-CT-based finite element analysis to accurately quantify peri-implant bone strains: a validation in rat tibiae

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