Generation of intestinal surface: an absorbing tale

Walton, Katherine D.; Freddo, Andrew M.; Wang, Sha; Gumucio, Deborah L.

doi:10.1242/dev.135400

Cited by 117 publications

(107 citation statements)

References 109 publications

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“…However, tools for genetic manipulation in a tissue specific manner are more limited in the chick. Additionally, there are significant differences between avian and mammalian gut development that may limit cross-species comparisons [18]. The embryonic mouse model develops in a similar time frame to the avian embryo (19–21 days), and as an advantage, has an extensive set of tools for tissue specific genetic manipulation.…”

Section: Models Of the Developing Intestinementioning

confidence: 99%

“…Villus morphogenesis is a process where the flat pseudostratified intestine begins to remodel and give rise to villus structures, which consist of finger-like epithelial protrusions into the intestinal lumen with an underlying mesenchymal core [18,23]. Villus formation massively expands the intestinal epithelial surface area, allowing for sufficient nutrient absorption to sustain life.…”

Section: Villus Formationmentioning

confidence: 99%

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Morphogenesis and maturation of the embryonic and postnatal intestine

Chin

Hill

Aurora

et al. 2017

Seminars in Cell & Developmental Biology

165

129

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The intestine is a vital organ responsible for nutrient absorption, bile and waste excretion, and a major site of host immunity. In order to keep up with daily demands, the intestine has evolved a mechanism to expand the absorptive surface area by undergoing a morphogenetic process to generate finger-like units called villi. These villi house specialized cell types critical for both absorbing nutrients from food, and for protecting the host from commensal and pathogenic microbes present in the adult gut. In this review, we will discuss mechanisms that coordinate intestinal development, growth, and maturation of the small intestine, starting from the formation of the early gut tube, through villus morphogenesis and into early postnatal life when the intestine must adapt to the acquisition of nutrients through food intake, and to interactions with microbes.

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Section: Models Of the Developing Intestinementioning

confidence: 99%

Section: Villus Formationmentioning

confidence: 99%

Morphogenesis and maturation of the embryonic and postnatal intestine

Chin

Hill

Aurora

et al. 2017

Seminars in Cell & Developmental Biology

165

129

View full text Add to dashboard Cite

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“…(Figure 3A) On the other hand, due to a thicker epithelium, it has been put forward that pattern formation in the mouse gut requires localized biochemical signals in addition to mechanical forces. [42–44]…”

Section: Computational Modeling Of Intestinal Organoid Systemsmentioning

confidence: 99%

Bioengineering for intestinal organoid cultures

Kim

Spence

Takayama

2017

Current Opinion in Biotechnology

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Recent advances allow access to human cell-based intestinal organoids that recreate human physiology to levels not possible with conventional 2D cell cultures. Despite their huge potential, there are many challenges that remain. This review will cover recent bioengineering approaches to improve organoid maturation, scale up, reproducibility and analysis. The first section covers the advances in engineering the culture environment, followed by the section on tools for micro-manipulation and analysis of organoids. The last section reviews the computational models developed to guide the use of engineered materials and tools, and to interpret observed results as well. The ability to use organoids for discovery research, and the need to both exert exquisite experimental control and obtain quantitative measurements from organoid models means that the field is ripe for collaborative efforts between biologists, engineers, clinicians and industry.

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“…Many prior studies have explored the feasibility of growing the different cells of the intestinal tract and loading these cells on biomaterials in the physical shape of intestine for in vivo implantation [17,33,34]. The concept is to utilize autologous tissue to obviate the need for immunosuppression.…”

Section: Biongineeringmentioning

confidence: 99%

“…The concept is to utilize autologous tissue to obviate the need for immunosuppression. A recently published review article specific to TESI highlights our current understanding of the morphologic and molecular fundamentals of TESI [33]. One group that has previously shown that human and murine TESI possess histologic features of small bowel has demonstrated the functional capacity of their TESI constructs [17].…”

Section: Biongineeringmentioning

confidence: 99%

New Insights and Interventions for Short Bowel Syndrome

Rouch

Dunn

2017

Curr Pediatr Rep

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Purpose of review This review summarizes recent innovations in the treatment of patients with short bowel syndrome. Recent findings The use of surgical procedures, growth factor stimulation, and bioengineering approaches to increase absorptive surface area of the intestine is examined. While the morphology of the intestine is clearly altered by these interventions, it is less clear that the overall function of the intestine is improved. Summary Continued innovations will likely bring about new therapeutic options for patients with short bowel syndrome. Careful evaluations of the impact of these interventions await controlled clinical trials.

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Generation of intestinal surface: an absorbing tale

Cited by 117 publications

References 109 publications

Morphogenesis and maturation of the embryonic and postnatal intestine

Morphogenesis and maturation of the embryonic and postnatal intestine

Bioengineering for intestinal organoid cultures

New Insights and Interventions for Short Bowel Syndrome

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