The optical vortex beams carrying orbital angular momentum (OAM) recently have unveiled great potential to be widely applied in advanced biomedicine, e.g. manipulating and assembling DNA, detecting biomolecule, organic illumination, single-cell nanosurgery, etc. However, it is an everlasting challenge to produce the proper vortices devices for corresponding applications. To this end, the tunable properties of OAM beams need to be produced. The spectrum-tunable property is related to the tuning of the response of target molecules. The OAM-tunable property can control the number and distribution of target particles. Moreover, the polarization-tunable property can be used to reduce photodamage. Hereinafter, we give a prompt review of the recent advances on tunable vortex beam devices for biomedical applications.