Generation of DPOAEs in the guinea pig

Withnell, Robert H.; Shaffer, Lauren A.; Talmadge, Carrick L.

doi:10.1016/s0378-5955(03)00064-9

Cited by 43 publications

(33 citation statements)

References 35 publications

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“…However, given the nontypical DLC and DPC results in one animal at one frequency that exhibited no DLC along with a DPC phase lead, we cannot rule out that there are two regions generating DPOAEs in the rat, such as that modeled by Shera and Guinan (1999), and that the MOC reflex affected one region more than the other. Although we have not tested for two DPOAE-emitting regions in SpragueYDawley rats by measuring microstructure, other rodents, such as guinea pigs (Withnell et al 2003) and kangaroo rats , do have some DPOAE microstructure.…”

Section: Mechanisms Underlying the Distortion Product Otoacoustic Emimentioning

confidence: 99%

Physiological Mechanisms of Onset Adaptation and Contralateral Suppression of DPOAEs in the Rat

Relkin

Sterns

Azeredo

et al. 2005

JARO

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An investigation was undertaken to measure medial olivocochlear (MOC) reflexes in anesthetized rats before and after sectioning of the middle-ear muscles. Distortion product otoacoustic emission (DPOAE) magnitude and phase temporal responses were measured ipsilaterally to study MOC-mediated BDPOAE onset adaptation^and in the presence of a contralateral noise to study MOC-mediated contralateral Bsuppression^(terms as used by previous researchers). Distortion product otoacoustic emission onset adaptation and contralateral suppression had predictable changes in direction of magnitude and phase that were dependent on the inputYoutput function. After sectioning of the middle-ear muscles (MEMs), DPOAE onset adaptation and contralateral suppression were greatly reduced, and there were little, if any, changes in phase. These Bresidualĉ hanges were interpreted as a result of the MOC reflex. The results suggest that what appears to be DPOAE onset adaptation and contralateral suppression can be mediated primarily by MEM reflexes. When studying MOC effects on otoacoustic emissions (OAEs) using acoustic stimulation, it is necessary to make recordings over a span of stimulus levels. In addition, looking at both magnitude and phase of the OAE may help separate what is due to the MOC reflex from MEM reflex.

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Section: Mechanisms Underlying the Distortion Product Otoacoustic Emimentioning

confidence: 99%

Physiological Mechanisms of Onset Adaptation and Contralateral Suppression of DPOAEs in the Rat

Relkin

Sterns

Azeredo

et al. 2005

JARO

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“…Distortion product otoacoustic emissions (DPOAEs) are known to be sensitive to early cochlear dysfunction, thus sensitively identifying a subclinical hearing loss. DPOAEs originate as a result of interaction of two simultaneous stimulus-related excitation patterns on the basilar membrane, which results in the emergence of a third tone at a specific frequency region of the basilar membrane (Kemp, 1986;Withnell, Shaffer & Talmadge, 2003). DPOAEs are preferred for the evaluation of cochlear functioning in view of their high test-retest reliability (Nikolopoulos et al, 1997) as well as their ability to evaluate a broader frequency range, thereby providing valuable information about the high-frequency range in particular.…”

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confidence: 99%

Cochlear function in patients with chronic kidney disease

Govender

Matthews

2013

South African Journal of Communication Disorders

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Objective: To evaluate cochlear functioning in patients (18 - 45 years old) with varying stages of chronic kidney disease (CKD). Using purposive sampling, 50 participants, 10 in each of the 5 stages of CKD, were selected and underwent pure tone audiometric testing and distortion product otoacoustic emissions (DPOAEs).Results: Significant differences (p<0.05) were found between pure tone audiometry and DPOAEs in detecting early cochlear dysfunction in the high-frequency range in stages 3 (6 000/5 000 Hz; p=0.00), 4 (6 000/5 000 Hz; p<0.03) and 5 (4 000/3 333 Hz; p<0.01, 8 000/6 667 Hz:p<0.05) with DPOAEs being more sensitive in identifying early cochlear dysfunction. Patients in stages 1 and 2 presented with normal puretone thresholds and DPOAEs, suggesting that cochlear functioning in these patients was normal. Early cochlear dysfunction, thereby indicating a subclinical hearing loss, was identified in stages 3, 4 and 5 by DPOAE testing. In addition, blood test results, drug intake and concomitant conditions were recorded and analysed which suggested a relationship between reduced cochlear functioning and increased electrolyte levels, treatment regimens and concomitant conditions.Conclusion: Participants in the later stages of CKD presented with early cochlear dysfunction, presenting with subclinical hearing loss. It was postulated that this subclinical hearing loss resulted from a combination of electrolytic, urea and creatinine imbalances, together with concomitant medical conditions and ototoxic drug intake. It was concluded that audiological monitoring be included in the management of patients with CKD and that DPOAEs be introduced as part of the test battery to monitor cochlear function in patients with varying degrees of CKD.

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“…1A, black lines). The amplitude and phase data obtained with and without wax present were converted to the time domain using a sequential inverse Fourier transform (IFFT) using the NIPR software package developed by Carrick Talmadge and described in Withnell et al [10]. These plots can be better understood if one looks at Fig.…”

Section: Resultsmentioning

confidence: 99%

Modification of DPOAE Fine Structure Stemming from Changes in Outer and Middle Ear Function

Henin¹,

Thompson²,

Shera³

et al. 2011

AIP Conference Proceedings

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Abstract. High resolution DPOAE fine structure was evaluated when the output impedance of the cochlea was modified by: (1) Changes in outer ear volume, due to accumulation of cerumen, which does not modify input impedance. (2) Manipulation of middle ear pressure and scarring of the tympanic membrane (which modify both input and output impedance). At high primary levels a wider and deeper DPOAE structure combined with (and sometimes dominated) DPOAE level fine structure. The group delay was also modified, sometimes giving rise to negative group delay. The data can be modeled by assuming that the increased impedance at the oval widow produces reflections back into the cochlea which can be re-reflected.

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Generation of DPOAEs in the guinea pig

Cited by 43 publications

References 35 publications

Physiological Mechanisms of Onset Adaptation and Contralateral Suppression of DPOAEs in the Rat

Physiological Mechanisms of Onset Adaptation and Contralateral Suppression of DPOAEs in the Rat

Cochlear function in patients with chronic kidney disease

Modification of DPOAE Fine Structure Stemming from Changes in Outer and Middle Ear Function

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