“…Moreover, combining different cardiac cell types into 3D tissue-like organoids promotes the maturity and function of iPSCs-derived cardiomyocytes (Giacomelli et al, 2017;Golforoush and Schneider, 2020). Recently, cardiac organoids containing four different cell types (cardiomyocytes, epicardial, endothelial cells, and cardiac fibroblast) derived from the same iPSC have been created (Helms et al, 2019). Furthermore, Lee and colleagues developed a 3D heart organoid comprised of cardiomyocytes, conducting tissues, endothelial and smooth muscle cells, with atrial and ventricular parts, myocardial contraction, and gene expression profiles resembling their in vivo counterparts (Lee et al, 2020).…”