Generation of Active Oxidant Species by Pulsed Dielectric Barrier Discharge in Water-Air Mixtures

Kornev, J.; Yavorovsky, N.; Preis, Sergei; Khaskelberg, M.; Isaev, U.; Chen, B.-N.

doi:10.1080/01919510600704957

Cited by 48 publications

(18 citation statements)

References 35 publications

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“…Recently, a few studies have reported that gas-phase pulsed corona discharges could be used to generate OH • radical, in addition to O 3 , effectively using air containing water vapor as the gas source [22][23][24][25], and the concentration of OH • radical generated was found to be several times higher than that of O 3 [23,26,27].…”

Section: Introductionmentioning

confidence: 99%

Degradation of Azo Dye Acid Red 88 by Gas Phase Dielectric Barrier Discharges

Tang

Jiang

Zhang

et al. 2009

Plasma Chem Plasma Process

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The degradation of an azo dye, acid red 88 (AR88) in aqueous solutions by a gas-phase dielectric barrier discharge (DBD) system was investigated. The reactive species generated from the DBD system such as OH • radical, ozone and hydrogen peroxide were measured. The effects of various parameters such as gas flow rate, initial pH, input power, initial concentration of AR88 and the gas source on the degradation of AR88 were studied. The results show that OH • radical was the major reactive species generated when 100% relative humidity (RH) air was used. An aqueous solution of 25 mg L -1 AR88 was 96.3% degraded in 5 min treatment, and 68% of the initial total organic carbon was removed in 90 min treatment with 100% RH air at 60 W input power and 7 L min -1 gas flow rate. The degradation kinetics of AR88 followed a pseudo-first-order reaction and was dependent on the input power, gas flow rate, initial AR88 concentration and initial pH.

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Section: Introductionmentioning

confidence: 99%

Degradation of Azo Dye Acid Red 88 by Gas Phase Dielectric Barrier Discharges

Tang

Jiang

Zhang

et al. 2009

Plasma Chem Plasma Process

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“…Application of optical fiber, lenses and collimators allowed us to obtain spectra of the plasma plume light emission at different locations with respect to the open end of the plasma gun. In these experiments the target placed at different distances from the open end of the plasma gun, was either dry or wet [37,38]. In general, different spectral lines of excited hydrogen, oxygen, nitrogen were detected [39].…”

Section: Resultsmentioning

confidence: 99%

Cold Atmospheric Plasma, Created at the Tip of an Elongated Flexible Capillary Using Low Electric Current, Can Slow the Progression of Melanoma

et al. 2017

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IntroductionCold Atmospheric Plasma Jet (CAPJ), with ion temperature close to room temperature, has tremendous potential in biomedical engineering, and can potentially offer a therapeutic option that allows cancer cell elimination without damaging healthy tissue. We developed a hand-held flexible device for the delivery of CAPJ to the treatment site, with a modified high-frequency pulse generator operating at a RMS voltage of <1.2 kV and gas flow in the range 0.3–3 l/min. The aims of our study were to characterize the CAPJ emitted from the device, and to evaluate its efficacy in elimination of cancer cells in-vitro and in-vivo.Methods and ResultsThe power delivered by CAPJ was measured on a floating or grounded copper target. The power did not drastically change over distances of 0–14 mm, and was not dependent on the targets resistance. Temperature of CAPJ-treated target was 23°-36° C, and was dependent on the voltage applied. Spectroscopy indicated that excited OH- radicals were abundant both on dry and wet targets, placed at different distances from the plasma gun. An in-vitro cell proliferation assay demonstrated that CAPJ treatment of 60 seconds resulted in significant reduction in proliferation of all cancer cell lines tested, and that CAPJ activated medium was toxic to cancer cells. In-vivo, we treated cutaneous melanoma tumors in nude mice. Tumor volume was significantly decreased in CAPJ-treated tumors relatively to controls, and high dose per fraction was more effective than low dose per fraction treatment. Importantly, pathologic examination revealed that normal skin was not harmed by CAPJ treatment.ConclusionThis preliminary study demonstrates the efficacy of flexible CAPJ delivery system against melanoma progression both in-vitro and in-vivo. It is envisioned that adaptation of CAPJ technology for different kinds of neoplasms use may provide a new modality for the treatment of solid tumors.

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“…The value of the capacitance obtained due to the simulation is a good estimation of its analytical counterpart obtained in [4] by the hybrid technique which involved the method of the integral equation and the method of Green function С = 1.74⋅10 -10 F/m. Let us note that the symmetric distribution of the electrostatic field allows us to determine the local capacities.…”

Section: Calculation Of the Electrostatic Fieldmentioning

confidence: 90%