Generation of a porcine cell line stably expressing pig TMPRSS2 for efficient isolation of viruses from pigs with respiratory diseases
Yuri L Tanaka,
Maya Shofa,
Erika P Butlertanaka
et al.
Abstract:Pigs are important animals for meat production but can carry several zoonotic diseases, including Japanese encephalitis virus, Nipah virus, and influenza viruses. SeveralOrthomyxoviridaeandCoronavirinaerespiratory viruses require cleavage of envelope proteins to acquire viral infectivity and consequently need a host protease or the addition of exogenous trypsin for efficient propagation. Host TMPRSS2 is a key protease responsible for viral cleavage. Stable expression of human TMPRSS2 in African green monkey-de… Show more
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