Generation and Characterization of a Transgenic Zebrafish Expressing the Reverse Tetracycline Transactivator

Gu, Qilin; Yang, Xiaojie; He, Xiaozhen; Li, Qing; Cui, Zongbin

doi:10.1016/j.jgg.2013.06.008

Cited by 21 publications

(17 citation statements)

References 41 publications

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“…Collection of eggs and culture of embryos were performed as in our previous study (Long et al, 2011a;Gu et al, 2013). Embryos were staged according to hour post-fertilization (hpf).…”

Section: Zebrafish Maintenance and Mc-lr Treatmentsmentioning

confidence: 99%

Zebrafish Abcb4 is a potential efflux transporter of microcystin-LR

Lü

Long

Sun

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Collection of eggs and culture of embryos were performed as in our previous study (Long et al, 2011a;Gu et al, 2013). Embryos were staged according to hour post-fertilization (hpf).…”

Section: Zebrafish Maintenance and Mc-lr Treatmentsmentioning

confidence: 99%

Zebrafish Abcb4 is a potential efflux transporter of microcystin-LR

Lü

Long

Sun

et al. 2015

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Total RNA was extracted from 20 homogenized zebrafish embryos exposed to each treatment using TRIzol (Invitrogen) according to the manufacturer's instruction, and single-stranded cDNA was systhesized as described previously [31,32].…”

Section: Rt-pcrmentioning

confidence: 99%

Effects of exposure to atrazine on retinoid signaling in zebrafish

Fan

Liu

et al. 2017

Preprint

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Atrazine is a widely used herbicide developed for use in range and pastureland. It is present in many surface waters, contaminating nontarget organisms due to its persistence. In this study, the effects of acute exposure to atrazine on retinoid signaling were investigated in zebrafish. Zebrafish embryos were exposed to atrazine from 6 hours post-fertilization (hpf) to 120 hpf. The contents of retinal and retinoic acid were decreased significantly. The mRNA

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“…The transparency of zebrafish embryos and high conservative evolutionary relationship to vertebrates, which make zebrafish a suitable model to investigate the genetic basis of human diseases [39][40][41]. The forward genetic screens of zebrafish makes this model powerful for discovery of novel gene functions in physiological process [42,43].…”

Section: Introductionmentioning

confidence: 99%

Toxicity of chlordane at early developmental stage of zebrafish

Xiong

2017

Preprint

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Chlordane is highly toxic organochlorine pesticides that have been widely used throughout the world for decades and posing adverse effects on the environment.Contents detected in tissue and blood samples have resulted in a raising concern for their potential effects on wildlife and humans. In this study, we investigate the potential effect of chlordane on the development of zebrafish embryos. Zebrafish larvae were treated with different concentrations (0, 25, 50, 100, 200 ng/L) of chlordane from 12 hours postfertilization (hpf). Different early stage parameters were observed at 1, 2, 3 and 4 day post-fertilization (dpf). Chlordane-exposed zebrafish larvae appeared significant lower survival rate, developmental and hatching time delay and decreased embryo productivity.The heartbeat rate and blood flow were decreased in a dose dependent manner. These results suggested that exposure to real life of chlordane led to direct morphological and phenotypic changes and effects systems related to development and reproduction even in short-term manner.

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Generation and Characterization of a Transgenic Zebrafish Expressing the Reverse Tetracycline Transactivator

Cited by 21 publications

References 41 publications

Zebrafish Abcb4 is a potential efflux transporter of microcystin-LR

Zebrafish Abcb4 is a potential efflux transporter of microcystin-LR

Effects of exposure to atrazine on retinoid signaling in zebrafish

Toxicity of chlordane at early developmental stage of zebrafish

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