2010
DOI: 10.1136/ard.2009.126383
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Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis

Abstract: ObjectivesTolerogenic dendritic cells (tolDCs) constitute a promising experimental treatment for targeting autoreactive T cells in autoimmune diseases, including rheumatoid arthritis (RA). The authors' goal is to bring tolDC therapy for RA to the clinic. Here the authors address key translational issues related to the manufacturing of tolDCs from RA patients with current good manufacturing practice (cGMP)-compliant reagents, the stability of tolDCs, and the selection of suitable quality control markers.Methods… Show more

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Cited by 186 publications
(184 citation statements)
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“…Similar results have been found in other models and also in parallel clinical studies using autologous DC 69, 70…”
Section: Discussionsupporting
confidence: 88%
“…Similar results have been found in other models and also in parallel clinical studies using autologous DC 69, 70…”
Section: Discussionsupporting
confidence: 88%
“…Use of tolDCs to induce antigen-specific anergy and/or Treg cells has been tested in several autoimmune animal models [18], including the EAE model [19]. Hence, several groups have designed immunotherapeutic approaches involving administration of tolDCs to humans to induce T-cell tolerance in transplantation and autoimmune diseases [20,21]. Different strategies have been evaluated to generate tolDCs in vitro, as recently reviewed [18,22].…”
Section: Introductionmentioning
confidence: 99%
“…However the adjuvant formulation immunized, failed to induce proliferation and recall-response to the ALT-2 antigen. This could be due to (1) low expression of co-stimulatory signals on APC (2) low production of proinflammatory cytokines (3) in sufficient production of memory cells, which result in impaired T cell proliferation, rendering T cells tolerant (Harry et al 2010).…”
Section: Lymphoproliferative Responsementioning
confidence: 99%