Generation and Application of Active Recombinant Mouse Tissue Factor and Its Function-blocking Monoclonal Antibody*

Pei, Xinhui; Shan, Changliang; Wang, Jintao; Lin, Zhongqiu; Zhang, Xuehong

doi:10.3724/sp.j.1206.2008.00639

PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS

2009

DOI: 10.3724/sp.j.1206.2008.00639

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Generation and Application of Active Recombinant Mouse Tissue Factor and Its Function-blocking Monoclonal Antibody*

Xinhui Pei

Changliang Shan

Jintao Wang

et al.

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2011

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“…Studies of influenza have also helped the fight against the threat of flu [20][21][22][23]. The development of monoclonal antibody techniques has facilitated the development of modern therapeutics for related diseases [24][25][26] and research on HIV has brought new opportunities to cure AIDS [27,28].…”

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Recent progress of immunology research in China

Leng

2011

Sci. China Life Sci.

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To celebrate the 60th anniversary of SCIENCE CHINA, the second issue of Science China Life Sciences (2010) focuses on immunology, with six articles contributed by immunologists working both in and outside China. The articles review the current position and recent developments in the field of immunology, including tumor necrosis factor (TNF) receptor-associated factor (TRAF) family molecules, innate recognition, plasmacytoid dendritic cells (pDCs), costimulatory molecules, T cells, and humanized mouse models.As early as 1798, the word "vaccination" was coined specifically to describe the injection of smallpox vaccine. In 1880, Louis Pasteur published a paper on Pasteurella septica cholera, heralding the beginning of a new scientific field: Immunology. From then on, Pasteur's germ theory of human infectious disease facilitated the development of various vaccines, leading to a greater understanding of the immune system which, in turn, resulted in the expansion of the field of Immunology. For a century, immunologists around the world have enhanced our understanding of the immune system; from humoral and cellular adaptive immunity to the pattern recognition involved in innate immunity. Alongside great advances due to the expansion of molecular biology over the past decade, Immunology has become a central pillar of the life sciences, developing many branches such as Medical Immunology, Tumor Immunology, Clinical Immunology and Transplantation Immunology. As an integral component of medical science, Immunology plays an important role in deepening the understanding of the pathophysiology of human disease, and also contributes to the development of modern therapeutics to treat infection, autoimmune diseases, allergies and cancer. In recent years, Chinese immunologists have produced many important studies in Immunology. The following reviews provide a brief overview of recent advances in Immunology, highlighting the contributions of leading Chinese immunologists.The first review "TRAF-mediated regulation of immune and inflammatory responses" by Wang et al. [1] focuses on the TRAF family, beginning with a comprehensive introduction to structure and function. Over the past few years, research studies have established a central role of TRAF proteins in inflammation and immunity. The TRAF family plays divergent and non-redundant roles in regulating the many signal transduction pathways involved in innate and adaptive immune responses. These molecules participate in signal transduction by a large number of receptor families, including the TNF receptor family and the Toll-like receptor-interleukin-1 receptor family. The review summarizes the divergent roles played by TRAF proteins in positive and negative regulation of the canonical and non-canonical NF-κB pathways and type I interferon pathways, and also points out many aspects of TRAF biology that, although not clear, may still be of great significance to related research.The second review is entitled "On self-non-self discrimination in pattern recognition" by Liu et al. [2]...

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Recent progress of immunology research in China

Leng

2011

Sci. China Life Sci.

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“…gene knockout and RNAi knockdown, provide significant tech-nical support; and increasing funding resources in China establish solid material basis for current immunology research. Noteworthy contributions made by Chinese laboratories in 2009 and 2010 include monoclonal antibodies production [28][29][30][31], studies on antigen-antibody binding site [32,33], Toll-like receptor (TLR) mediated signaling pathways [34,35], inflammasome and inflammatory response [36][37][38], and HIV-1 infection [39,40]. Owing to constant and steady increase of funding resources as well as progressively improved research conditions, more significant achievements generated in domestic laboratories in China are highly expected.…”

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Some latest achievements in immunology research

Wei

2011

Chin. Sci. Bull.

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Immunology has become as an attractive discipline of biomedical science in the 21st century, integrated with the rapid development of molecular biology, cell biology, structural biology, genetics and other branches in life sciences. A special issue of Sci China Life Sci was published in February 2010 to highlight recent progresses in immunology. Six review articles focusing on various specific topics were contributed by leading scientists who work in respective fields of immunology. Some progresses of immunology research in China are also described. Immunity, the concept from immunis, a Latin word meaning "exempt", can be traced back to the plaque of Athens in 430 BC. Many other ancient nations have documented that people who had recovered from a previous bout of the disease would acquire mysterious ability to avoid contracting the illness for the second time. Early forms of vaccination were developed long before the word vaccination was first introduced by Edward Jenner in 1796 to specifically describe the injection of smallpox vaccine, but it was not until the 19th and 20th centuries before the concept developed into scientific theory [1]. In the 21st century, immunology has become an indispensable branch of biomedical science that covers the study of all aspects of the immune system, and broadened its horizons with much research being performed in the more specialized niches, such as clinical immunology, developmental immunology, evolutionary immunology, cancer immunology and immunotherapy. Immunology deals with not only functioning of the immune system in health state, but malfunctions of the immune system in immunological disorders as well, thus deepening understanding of pathophysiology of human diseases and contributing to therapeutical and pharmaceutical developments. Vertebrates have evolved to protect themselves against infections by two different means: innate immunity and adaptive immunity, while invertebrates rely on innate immunity only. Both immune responses are tightly regulated in all organisms to prevent over-reaction and maintain immunological homeostasis [2][3][4]. In 1989, Janeway proposed a revolutionary concept that adaptive immunity is initiated by pattern recognition of innate immunity [5]. In a minireview article published on the special issue of immunology, Liu et al. [6] provided the first experimental evidence that microbial recognition by the innate immune system turns on the adaptive immune system and explained how the immune system controls the balance between sensing pathogenassociated molecular patterns (PAMPs) and the self-dangerassociated molecular patterns (DAMPs). Their previous work demonstrated the existence of costimulatory activity of bacterial components and the need of cis-presentation of both antigen and costimulartors for T cell activation [7,8].

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Generation and Application of Active Recombinant Mouse Tissue Factor and Its Function-blocking Monoclonal Antibody*

Cited by 2 publications

References 15 publications

Recent progress of immunology research in China

Recent progress of immunology research in China

Some latest achievements in immunology research

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