2024
DOI: 10.1088/1758-5090/ad2fd5
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Generating human skeletal myoblast spheroids for vascular myogenic tissue engineering

Mendy Minne,
Lisanne Terrie,
Rebecca Wüst
et al.

Abstract: Engineered myogenic microtissues derived from human skeletal myoblasts offer unique opportunities for varying skeletal muscle tissue engineering applications, such as in vitro drug-testing and disease modelling. However, more complex models require the incorporation of vascular structures, which remains to be challenging. In this study, myogenic spheroids were generated using a high-throughput, non-adhesive micropatterned surface. Since monoculture spheroids containing human skeletal myoblasts were unable to r… Show more

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