Generating an Artificial Intestine for the Treatment of Short Bowel Syndrome

Kovler, Mark L.; Hackam, David J.

doi:10.1016/j.gtc.2019.08.011

Cited by 9 publications

(6 citation statements)

References 133 publications

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“…90,91 Others have attempted to grow artificial intestines using intestinal stem cells onto a biological scaffold. 92,93 These can then be implanted into the patient with short bowel syndrome to provide additional absorptive capacity. Studies in this space thus far have been limited mostly to proofs of concept without evidence of much clinical benefit.…”

Section: The Future Of Inte S Tinal Rehab Ilitation and Tr Ans Pl Antmentioning

confidence: 99%

“…Recently, animal models have shown that surgically inserted springs may support intestinal lengthening 90,91 . Others have attempted to grow artificial intestines using intestinal stem cells onto a biological scaffold 92,93 . These can then be implanted into the patient with short bowel syndrome to provide additional absorptive capacity.…”

Section: The Future Of Intestinal Rehabilitation and Transplantmentioning

confidence: 99%

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From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide

Raghu,

Rumbo,

Horslen

2024

Pediatric Transplantation

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IntroductionIntestinal failure, defined as the loss of gastrointestinal function to the point where nutrition cannot be maintained by enteral intake alone, presents numerous challenges in children, not least the timing of consideration of intestine transplantation.ObjectivesTo describe the evolution of care of infants and children with intestinal failure including parenteral nutrition, intestine transplantation, and contemporary intestinal failure care.MethodsThe review is based on the authors' experience supported by an in‐depth review of the published literature.ResultsThe history of parenteral nutrition, including out‐patient (home) administration, and intestine transplantation are reviewed along with the complications of intestinal failure that may become indications for consideration of intestine transplantation. Current management strategies for children with intestinal failure are discussed along with changes in need for intestine transplantation, recognizing the difficulty in generalizing recommendations due to the high level of heterogeneity of intestinal pathology and residual bowel anatomy and function.DiscussionAdvances in the medical and surgical care of children with intestinal failure have resulted in improved transplant‐free survival and a significant fall in demand for transplantation. Despite these improvements a number of children continue to fail rehabilitative care and require intestine transplantation as life‐saving therapy or when the burden on ongoing parenteral nutrition becomes too great to bear.

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Section: The Future Of Inte S Tinal Rehab Ilitation and Tr Ans Pl Antmentioning

confidence: 99%

Section: The Future Of Intestinal Rehabilitation and Transplantmentioning

confidence: 99%

From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide

Raghu,

Rumbo,

Horslen

2024

Pediatric Transplantation

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“…From the more surgical point of view, we reviewed non-transplant and transplant option available, however they are not always effective and safe. The most promising new frontier and opportunity for research in this field seems to be represented by the intestine’s own capacity for regeneration and the creation of a tissue-engineered SI from stem cells (206).…”

Section: Research Gaps and Future Perspectivesmentioning

confidence: 99%

Nutrition and Intestinal Rehabilitation of Children With Short Bowel Syndrome: A Position Paper of the ESPGHAN Committee on Nutrition. Part 2: Long-Term Follow-Up on Home Parenteral Nutrition

Norsa,

Goulet,

Alberti

et al. 2023

Journal of Pediatric Gastroenterology &Amp; Nutrition

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Short bowel syndrome (SBS) is the leading cause of intestinal failure (IF) in children. The preferred treatment for IF is parenteral nutrition which may be required until adulthood. The aim of this position paper is to review the available evidence on managing SBS and to provide practical guidance to clinicians dealing with this condition. All members of the Nutrition Committee of the European Society for Paediatric Gastroenterology Hepatology and Nutrition (ESPGHAN) contributed to this position paper. Some renowned experts in the field joined the team to guide with their expertise. A systematic literature search was performed from 2005 to May 2021 using PubMed, MEDLINE, and Cochrane Database of Systematic Reviews. In the absence of evidence, recommendations reflect the expert opinion of the authors. Literature on SBS mainly consists of retrospective single-center experience, thus most of the current papers and recommendations are based on expert opinion. All recommendations were voted on by the expert panel and reached >90% agreement. This second part of the position paper is dedicated to the long-term management of children with SBS-IF. The paper mainly focuses on how to achieve intestinal rehabilitation, treatment of complications, and on possible surgical and medical management to increase intestinal absorption.

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“…25 cm), small intestine = convoluted tube with D = [2.5-4] cm, L = [2-4] m, large intestine: D = approx. 7 cm, L = 1.5 m [Egorov et al, 2002;Marieb and Hoehn, 2010;Bitar et al, 2014;Luc et al, 2014;Maghsoudlou et al, 2014;Fedoruk and Hong, 2014;Londono and Badylak, 2015;Jensen et al, 2015;Poghosyan et al, 2016;Arakelian et al, 2018;Urbanska et al, 2018;Noh, 2018;Dosh et al, 2018;Hussey et al, 2018;Kanetaka et al, 2018;Kanetkar and Ekenseair, 2019;Kovler and Hackam, 2019;Jones et al, 2019;Qi et al, 2020] MR: [Lomholt, 1992;Habib et al, 1994;Gregersen and Kassab, 1996;Rao et al, 1996;…”

Section: Processing Techniques For the Development Of Tubular Constru...mentioning

confidence: 99%

Tubular Bioartificial Organs: From Physiological Requirements to Fabrication Processes and Resulting Properties. A Critical Review

Pien

Palladino

Copes

et al. 2021

Cells Tissues Organs

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In this featured review manuscript, the aim is to present a critical survey on the processes available for fabricating bioartificial organs (BAOs). The focus will be on hollow tubular organs for the transport of anabolites and catabolites, i.e., vessels, trachea, esophagus, ureter and urethra, and intestine. First, the anatomic hierarchical structures of tubular organs, as well as their principal physiological functions, will be presented, as this constitutes the mandatory requirements for effectively designing and developing physiologically relevant BAOs. Second, 3D bioprinting, solution electrospinning, and melt electrowriting will be introduced, together with their capacity to match the requirements imposed by designing scaffolds compatible with the anatomical and physiologically relevant environment. Finally, the intrinsic correlation between processes, materials, and cells will be critically discussed, and directives defining the strengths, weaknesses, and opportunities offered by each process will be proposed for assisting bioengineers in the selection of the appropriate process for the target BAO and its specific required functions.

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Generating an Artificial Intestine for the Treatment of Short Bowel Syndrome

Cited by 9 publications

References 133 publications

From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide

From intestinal failure to transplantation: Review on the current need for transplant indications under multidisciplinary transplant programs worldwide

Nutrition and Intestinal Rehabilitation of Children With Short Bowel Syndrome: A Position Paper of the ESPGHAN Committee on Nutrition. Part 2: Long-Term Follow-Up on Home Parenteral Nutrition

Tubular Bioartificial Organs: From Physiological Requirements to Fabrication Processes and Resulting Properties. A Critical Review

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