Let R be a Dedekind ring, p a nonzero prime ideal of R, P ∈ R[X] a monic irreducible polynomial, and K the quotient field of R. We give in this paper a lower bound for the p-adic valuation of the index of P over R in terms of the degrees of the monic irreducible factors of the reduction of P modulo p. As an important application, when the lower bound is greater than zero for some p, we conclude that no root of P generates a power integral basis in the field extension of K defined by P .