This is a follow-up paper of [Gol18], where rational curves in surfaces that satisfy general positioned point and cross-ratio conditions were enumerated. A suitable correspondence theorem provided in [Tyo17] allowed us to use tropical geometry, and, in particular, a degeneration technique called floor diagrams. This correspondence theorem also holds in higher dimension.In the current paper, we introduce so-called cross-ratio floor diagrams and show that they allow us to determine the number of rational space curves that satisfy general positioned point and cross-ratio conditions. Moreover, graphical contributions are introduced which provide a novel and structured way of understanding multiplicities of floor decomposed curves in R 3 . Additionally, socalled condition flows on a tropical curve are used to reflect how conditions imposed on a tropical curve yield different types of edges. This concept is applicable in arbitrary dimension. Notation 1.1. We write [m] ∶= {1, . . . , m} if 0 ≠ m ∈ N, and if m = 0, then define [m] ∶= ∅.Underlined symbols indicate a set of symbols, e.g. n ⊂ [m] is a subset {1, . . . , m}. We may also use sets S of symbols as an index, e.g. p S , to refer to the set of all symbols p with indices taken from S, i.e. p S ∶= {p i i ∈ S}. The #-symbol is used to indicate the number of elements in a set, for example #[m] = m.