Generalized Xanthoma Tuberosum With Xanthomatous Changes in Fresh Scars of an Intercurrent Zoster

The Relationship Between Serum Lipids and Skin Xanthomata in Eighteen Patients With Primary Biliary Cirrhosis

“…The serum lipid pattern which is characteristic of "primary biliary cirrhosis" has also been found in this Hospital in obstructive jaundice of other types: in extrahepatic biliary obstruction (two cases), occasionally in congenital bile duct atresia (two cases), and in severely jaundiced patients with infectious hepatitis (five cases), and has elsewhere been reported in these conditions (18)(19)(20)(21) and in arsenical liver injury (22,23). Moreover, it has been noted in experimental bile duct ligation in rats (24,25).…”

Hepatobiliary Pseudotumors Consisting of Nonneoplastic Hematopoietic Cells and Cells of the Macrophage Lineage

“…A xanthomatous mass at the liver hilum has been described in a 9-year-old boy with generalized xanthomatosis and xanthoma tuberosum (Weidman and Freeman 1924). Xanthomas may also involve the liver capsule (Weidman and Boston 1937). In hyperlipoproteinemia associated with extensive xanthoma tuberosum, hepatocytes in addition to macrophages may take part in lipid storage, sometimes resulting in parenchymal changes reminiscent of adrenocortical tissue (Weidman and Stokes 1937).…”

“…At gross examination, the lesions are spheroid to oblong, elevated, rather sharply delineated spots or patches, sometimes showing a dimple in the center (molluscum-like lesions). In some patients, the involved bile ducts were dilated, had thickened walls, and were lined by bright yellow granular incrustive material (Weidman and Boston 1937). In an another patient, the walls of the bile ducts were of a deep yellow color, and there were minute yellow flecks in the mucosa of the bile ducts (Futcher 1905).…”

“…Histology is characterized by a patchy accumulation of foam cells involving the mucosa and, in larger lesions, inner parts of the bile duct muscularis. The lesions may be accompanied by impressive hyperplasia of the peribiliary glands (Weidman and Boston 1937) and by scarring causing stenosis or even obstruction (Weidman and Boston 1937;Thannhauser and Magendantz 1938). The pathology has already been described in early reports.…”