Generalized versus Patient-Specific Inflow Boundary Conditions in Computational Fluid Dynamics Simulations of Cerebral Aneurysmal Hemodynamics

Jansen, Ingrid; Schneiders, J.J.; Potters, Wouter V.; Ooij, Pim van; Berg, René van den; VanBavel, Ed; Marquering, Henk A.; Majoie, Charles B. L. M.

doi:10.3174/ajnr.a3901

Cited by 74 publications

(53 citation statements)

References 36 publications

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“…Furthermore, patient-specific boundary conditions could help increase the translational potential of CFD, at least, until robust parameters will be described and strongly correlated with rupture. Studies have shown using generic instead of patient-specific velocities can have significant effects on results, such as WSS, high WSS location, and inflow jet stability 29. The latest CFD challenges have demonstrated this variability, the impact of the segmentation on the hemodynamic parameters and, more critical, the failure of most of the CFD results to accurately predict the rupture using hemodynamic parameters.…”

Section: Discussion and Limitationsmentioning

confidence: 99%

Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture – a systematic review and novel parameter-ranking tool

Liang

Steinman

Brina

et al. 2018

J NeuroIntervent Surg

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BackgroundIntracranial aneurysms (IAs) are vascular dilations on cerebral vessels that affect between 1%–5% of the general population, and can cause life-threatening intracranial hemorrhage when ruptured. Computational fluid dynamics (CFD) has emerged as a promising tool to study IAs in recent years, particularly for rupture risk assessment. However, despite dozens of studies, CFD is still far from clinical use due to large variations and frequent contradictions in hemodynamic results between studies.PurposeTo identify key gaps in the field of CFD for the study of IA rupture, and to devise a novel tool to rank parameters based on potential clinical utility.MethodsA Pubmed search identified 231 CFD studies for IAs. Forty-six studies fit our inclusion criteria, with a total of 2791 aneurysms. For included studies, study type, boundary conditions, solver resolutions, parameter definitions, geometric and hemodynamic parameters used, and results found were recorded.Data synthesisAspect ratio, aneurysm size, low wall shear stress area, average wall shear stress, and size ratio were the parameters that correlate most strongly with IA rupture.LimitationsSignificant differences in parameter definitions, solver spatial and temporal resolutions, number of cycles between studies as well as frequently missing information such as inlet flow rates were identified. A greater emphasis on prospective studies is also needed.ConclusionsOur recommendations will help increase standardization and bridge the gaps in the CFD community, and expedite the process of making CFD clinically useful in guiding the treatment of IAs.

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Section: Discussion and Limitationsmentioning

confidence: 99%

Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture – a systematic review and novel parameter-ranking tool

Liang

Steinman

Brina

et al. 2018

J NeuroIntervent Surg

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“…Hence, if CFD is integrated in clinical routines some day, guidelines that have evolved from years of experience (eg, spatial and temporal discretization, flow rates, and so forth) should be provided. Such guidelines for hemodynamic simulations in intracranial aneurysms need to address the choice of inflow boundary condition (eg, idealized versus patient-specific 22 ), flow splitting through multiple outlet sections, wall treatment, blood modeling, and the consideration of pulsatile flow (steady versus unsteady 23 ), and so forth. Overall, the following knowledge can be derived from this CFD challenge, which should be considered a snapshot of the current state-of-the-art regarding hemodynamic simulations.…”

Section: Discussionmentioning

confidence: 99%

The Computational Fluid Dynamics Rupture Challenge 2013—Phase I: Prediction of Rupture Status in Intracranial Aneurysms

Janiga¹,

Berg²,

Sugiyama

et al. 2014

AJNR Am J Neuroradiol

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“…CFD calculations based on stereotypical velocity inputs are subject to significant errors based on their sensitivity to pressure and/or flow rate waveform boundary conditions (Karmonik et al 2010, Jansen et al 2014, Marzo et al 2011, McGah et al 2014, Venugopal et al 2007). Indeed, recent controversy has originated over the accuracy of CFD using either stereotypical literature-based or patient-specific flow rates for haemodynamic simulations of intracranial aneurysms (Steinman 2011).…”

Section: Introductionmentioning

confidence: 99%

In vitrovalidation of endovascular Doppler-derived flow rates in models of the cerebral circulation

et al. 2015

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This study presents validation of endovascular Doppler velocimetry-based volumetric flow rate measurements conducted in a pulsatile flow loop simulating conditions in both the internal carotid and basilar artery. In vitro models of cerebral vessels, each containing an aneurysm, were fabricated from patient anatomies extracted from 3D rotational angiography. Flow velocity measurements were collected with three different experimental techniques: an endovascular Doppler wire, Particle Image Velocimetry, and a time-resolved ultrasonic flow meter. Womersley’s theory of pulsatile flow in a cylindrical vessel was used to compute time-resolved volumetric flow rates from the endovascular Doppler velocity. The volumetric flow rates computed from the Doppler measurements were compared to those from the Particle Image Velocimetry profile measurements, and the direct measurements from the ultrasonic flow meter. The study establishes confidence intervals for any systematic or random errors associated with the wire-derived flow rates as benchmarked to the other two modalities. There is an approximately 10% random error in the Doppler-derived peak and time-averaged flow rates. There is a measurable uniform bias, about 15% too low, in the time-averaged Doppler-derived flow rates. There is also a small proportional bias in the peak systolic Doppler-derived flow rates. Potential sources of error are also discussed.

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Generalized versus Patient-Specific Inflow Boundary Conditions in Computational Fluid Dynamics Simulations of Cerebral Aneurysmal Hemodynamics

Cited by 74 publications

References 36 publications

Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture – a systematic review and novel parameter-ranking tool

Towards the Clinical utility of CFD for assessment of intracranial aneurysm rupture – a systematic review and novel parameter-ranking tool

The Computational Fluid Dynamics Rupture Challenge 2013—Phase I: Prediction of Rupture Status in Intracranial Aneurysms

In vitrovalidation of endovascular Doppler-derived flow rates in models of the cerebral circulation

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