“…Considering four blocks instead, the 2 8−3 IV design was made by rearranging M2 in the order 32, 4,5,25,30,18,3,15,12,24,17,13,10,6,23,27,28,8,1,29,26,22,7,11,16,20,21,9,14,2,19 and 31. The columns 3, 7, 29, 4 and 15 were used to define factors A, B, C, D and E, respectively.…”