Generalized seizures alter the cerebral and peripheral metabolism of essential metals in mice

Papavasiliou, Paul S.; Miller, Samuel T.

doi:10.1016/0014-4886(83)90257-1

Cited by 27 publications

(15 citation statements)

References 27 publications

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“…Moreover, this decreased activity is of the same order of magnitude as the decreased concentration of Mn2+ reported in the comparison of these same strains (Carl et al, 1990). On the other hand, chronic seizure activity induced in normal rats had no effect on brain Mn2+ concentration (Table l), an observation that does not agree with the results of Papavasiliou and Miller (1983) showing that chronic seizure activity in mice caused a decrease in brain Mn2+ concentration.…”

Section: Abbreviations As Incontrasting

confidence: 63%

“…The conclusion by Papavasiliou et al (1979) and Papavasiliou and Miller (1983) that the seizures themselves are responsible for changes in tissue Mn2+ concentrations observed in association with seizures appears to be at least partially correct in that seizures do appear to affect Mn2+ concen- GEPRs, genetically epilepsy-prone rats; SDRs, nonepileptic Spmgue-Dawley rats.…”

Section: Resultsmentioning

confidence: 91%

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Manganese and Epilepsy: Brain Glutamine Synthetase and Liver Arginase Activities in Genetically Epilepsy Prone and Chronically Seizured Rats

et al. 1993

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Low blood manganese (Mn2+) concentration is associated with epilepsy in humans and rats. The low Mn2+ concentration is attributed by some investigators to the seizure activity associated with the epilepsy, whereas others propose that the low Mn2+ concentration may be secondary to genetic mechanisms underlying the epilepsy. To begin to differentiate between these possibilities, Mn(2+)-binding enzymes of liver and brain (i.e., arginase and glutamine synthetase, respectively) were assayed in rats exposed to chronically induced seizures and in genetically epilepsy-prone rats (GEPRs). Chronic seizures caused a decrease in whole blood Mn2+ levels but did not affect brain Mn2+ concentrations. Arginase activity was increased in livers of rats with chronic seizure as compared with controls, but this difference was eliminated when Mn2+ was added to the assay. Brain glutamine synthetase activity was unaffected by chronic seizures, but the activity of this enzyme was significantly lower in GEPR brain than in control brain. Liver arginase activity tended to be lower in GEPRs, although the difference was not statistically significant. These data indicate that seizures affect liver arginase activity through changes in liver Mn2+ concentration, but GEPRs show abnormalities in Mn(2+)-dependent enzymes apparently independent of seizure activity.

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Section: Abbreviations As Incontrasting

confidence: 63%

Section: Resultsmentioning

confidence: 91%

Manganese and Epilepsy: Brain Glutamine Synthetase and Liver Arginase Activities in Genetically Epilepsy Prone and Chronically Seizured Rats

et al. 1993

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“…Hence, these elements are responsible for various metabolic processes, including those occurring in the brain (16). Existing evidence suggests that epileptic seizures signifi cantly change the metabolism and distribution of trace elements in the nervous tissue (17)(18)(19). On the other hand, metal contents determine susceptibility to convulsions (20).…”

Section: Discussionmentioning

confidence: 99%

Major and minor bio-element status in children with febrile seizure

Akbayram¹,

Cemek²,

Büyükben³

et al. 2012

BLL

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Febrile seizures (FS) are the most common cause of seizures in children. The exact etiopathogenesis is unknown but involves factors like genetic predisposition and alterations in the levels of neurotransmitters and some trace elements. The study includes 48 consecutive children with FS, and 55 healthy age matched control subjects. Calcium, magnesium and potassium concentrations in the febrile study group were lower than in the control group (p<0.05). Iron and Gallium levels in the study group were lower than in the control group (p<0.01). Serum Selenium (p<0.001), Zinc (p<0.001) and Strontium (p<0.05) levels were signifi cantly decreased in the study group when compared to the control group. There was no signifi cant difference between the control and study groups in Serum Barium, Beryllium and Copper levels (p>0.05). The aim of the present prospective analytical case-control study was to determine whether there was any change in element levels in children with FS (Ref. 33). Full Text in PDF www.elis.sk.

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“…Existing evidence suggests that epileptic seizures significantly change metabolism and distribution of trace elements in the nervous tissue [6][7][8]. From the other hand, content of metals determinates susceptibility to convulsions [9].…”

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confidence: 99%

The role of trace elements in the pathogenesis and progress of pilocarpine-induced epileptic seizures

et al. 2008

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Epilepsy, the third most common neurological disorder, is characterized by recurrent unprovoked seizures. Although the mechanisms of epileptic convulsions have been a subject of intensive investigations for many years in most cases the etiology of the disease is not known [1].Metallic elements participating in the processes like: oxidative stress, excitotoxicity, mitochondrial dysfunction or protein aggregation may lead to the atrophy and death of neurons in case of some neurodegenerative disorders [2][3][4]. Because epileptic seizures induce neurodegeneration in selected areas of brain it is suspected that metals may be involved in the pathogenesis and progress of epilepsy as well [5].Existing evidence suggests that epileptic seizures significantly change metabolism and distribution of trace elements in the nervous tissue [6][7][8]. From the other hand, content of metals determinates susceptibility to convulsions [9].In our experiment we used pilocarpine in order to induce epilepsy in rats. In order to find what elements are involved in the pathogenesis and progress of epileptic convulsions the comparison between pilocarpine treated and control rats was done. The samples of rat brain were cut using a cryomicrotome into 15 µm thick slices. Thin tissue sections were mounted on Ultralene foil and freeze-dried.X-ray fluorescence microscopy was employed for topographic and quantitative analysis of selected metals in the areas of brain tissue involved in epilepsy. The measurements were done on the bending magnet beamline L at HASYLAB. The multilayer monochromator was applied and the primary photon energy was set to 17 keV. The beam was focused with polycapillary optics for a final beam spot dimension of 15 µm x 15 µm. The characteristic X-ray lines were measured using the Vortex SDD detector from SII Nano Technology USA inc. and the time of spectra acquisition was equal to 6 s per pixel. Measurements of NIST standard reference materials (SRM 1833 and SRM 1832) were performed for spectrometer calibration.The elements such us P, S, Cl, K, Ca, Fe, Cu, Zn, Br, Rb and Sr were detected in rat brain sections. For each sample two-dimensional analysis of elemental distribution was performed for the area of hippocampus and brain cortex. The results of such analysis for selected control and epileptic sample were shown in Figures 1 and 2 respectively.For four regions of hippacampus formation (CA1 -Cornu Ammonis, CA3, DG -Dentate Gyrus and H -Hilus) and motor cortex the mean masses per unit area were evaluated. The areas taken into account in calculations were equal to 300 µm per 300 µm. The preliminary results showed that the level of Ca tends to be higher for CA1 region of hippocampus and cortex in case of animals with pilocarpine induced epilepsy. The opposite relation was observed for Zn level in the area of DG.1551

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Generalized seizures alter the cerebral and peripheral metabolism of essential metals in mice

Cited by 27 publications

References 27 publications

Manganese and Epilepsy: Brain Glutamine Synthetase and Liver Arginase Activities in Genetically Epilepsy Prone and Chronically Seizured Rats

Manganese and Epilepsy: Brain Glutamine Synthetase and Liver Arginase Activities in Genetically Epilepsy Prone and Chronically Seizured Rats

Major and minor bio-element status in children with febrile seizure

The role of trace elements in the pathogenesis and progress of pilocarpine-induced epileptic seizures

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