This paper generalizes the cointegrated vector autoregressive model of Johansen (1988) to allow for structural changes. Estimation under various hypotheses is made possible by a new estimation technique, that makes it simple to derive a number of interesting likelihood ratio tests. E.g., the test for m structural changes against m + k structural changes (occurring at fixed points in time), m ∈ N 0 , k ∈ N, and test of linear parameter restrictions when the null hypothesis allows for structural changes. The asymptotic distribution is χ 2 in both cases.The model is applied to US term structure data, and structural changes in September 1979 and October 1982 -points in time with large changes in the Fed's policy -are found to be significant. After accounting for these structural changes, I cannot, contrary to previous studies, reject the long-run implications of the expectations hypothesis.