Generalized Pustular Rash Associated With Primary Atypical Pneumonia

Abstract

After the acute onset of primary atypical pneumonia, a 4-year-old girl suddenly developed a widespread, sterile, pustular eruption with predilection toward the distal parts of the extremities. There was no involvement of the muco-ocular area. Histological and electron microscopical examinations revealed intraepidermaI pustule formation containing neutrophils and eosinophils, and perivascular infiltration of lymphocytes, histiocytes, neutrophils and eosinophils. These clinical findings are similar to those of Tan's "acute generalized pustular bacterid" and Teisch's "vesiculopustular eruption with mycoplasma infection". Serological examinations, including complement fixation test, cold agglutination test, and passive hemagglutination test, confirmed a Mycoplasma pneumoniae infection. It is concluded that Mycoplasma pneumoniae infection should be considered in patients with bacterid-like rashes who do not have streptococcal infections.

Subcorneal pustular dermatosis triggered by Mycoplasma pneumoniae infection: a rare clinical association

“…Seven possible cases were identified ( Table 1, top). [3][4][5][6][7][8][9] Their characteristics matched our patient's clinical and histopathological presentation. Patients were young men (M/F ratio: 3/1, mean age: 17 years).…”

“…Biofilms were defined as surface-associated matrix-encased bacterial cell clusters of >1000 bacterial cells. 5 Samples scored positive for Gram-positives or DAPI-labelled cocci were further tested with a PNA-FISH kit (AdvanDx A/S, Vedbaek, Denmark). This kit is designed to distinguish S. aureus from coagulase-negative staphylococci (CNS).…”