Generalized pustular psoriasis precipitated by topical calcipotriol ointment

Tamiya, Hisashi; Fukai, Kazuyoshi; Moriwaki, K; Ishii, Masamitsu

doi:10.1111/j.1365-4632.2004.02519.x

Cited by 12 publications

(9 citation statements)

References 6 publications

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“…However, as in topical steroids, topical active form vitamin D 3 has been used frequently in combination with systemic therapy (Table ), providing a reasonable basis for its use. However, careful attention must be paid when using topical active form vitamin D 3 because of some case reports showing the induction of GPP …”

Section: Chapter V: Strength Of Recommendations and Comments For Eachmentioning

confidence: 99%

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

192

456

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Generalized pustular psoriasis (GPP) is a rare disease characterized by recurrent fever and systemic flushing accompanied by extensive sterile pustules. The committee of the guidelines was founded as a collaborative project between the Japanese Dermatological Association and the Study Group for Rare Intractable Skin Diseases under the Ministry of Health, Labour, and Welfare Research Project on Overcoming Intractable Diseases. The aim of the guidelines was to provide current information to aid in the treatment of patients with GPP in Japan. Its contents include the diagnostic and severity classification criteria for GPP, its pathogenesis, and recommendations for the treatment of GPP. Since there are few clinical trial data with high levels of evidence for this rare disease, recommendations by the committee are described in the present guidelines.

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Section: Chapter V: Strength Of Recommendations and Comments For Eachmentioning

confidence: 99%

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Fujita

Terada

Hayama

et al. 2018

The Journal of Dermatology

192

456

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“…In some cases they induced a flare of pustular psoriatic lesions (23,24). A possible pathogenetic explanation is that when irritation by topical vitamin D occurs, keratinocytes release inflammatory cytokines, including IL-1, IL-6, TNF-a and IFN-c, that induce an aggravation of the disease (23).…”

Section: Discussionmentioning

confidence: 99%

Acrodermatitis continua of Hallopeau on toes successfully treated with a two‐compound product containing calcipotriol and betamethasone dipropionate

Sotiriadis

Patsatsi

Sotiriou

et al. 2007

Journal of Dermatological Treatment

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In our patient, calcipotriol/ betamethasone dipropionate ointment was an efficacious regimen in the treatment of ACH. In the era of biologics, old topical agents in combined forms remain valuable. Although calcipotriol alone or its combination with betamethasone have been reported to aggravate the disease in some cases, their beneficial role is important and they are worth considering as first line therapeutic agents in the management of various forms of pustular psoriasis.

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“…9 Since then, topical calcipotriol has become one modality for treating pustular psoriasis, although there were two reports implicating topical calcipotriol as a possible precipitating factor of the condition. 10,11 Because our patient is still young, we selected topical application of a low concentration of vitamin D 3 (2 μg/g tacalcitol) and a weak class of corticosteroid instead of oral retinoid or cyclosporin. This topical therapy resulted in gradual improvement in the skin lesions, although there remained a possibility that oral hydrocortisone therapy for steroid withdrawal syndrome would also be effective for skin lesions of pustular psoriasis.…”

Section: Juvenile Pustular Psoriasis Associated With Steroid Withdrawmentioning

confidence: 99%

“…The efficacy of topical calcipotriol (50 µg/g), a synthetic vitamin D 3 analog, was first reported in 1992 9 . Since then, topical calcipotriol has become one modality for treating pustular psoriasis, although there were two reports implicating topical calcipotriol as a possible precipitating factor of the condition 10,11 . Because our patient is still young, we selected topical application of a low concentration of vitamin D 3 (2 µg/g tacalcitol) and a weak class of corticosteroid instead of oral retinoid or cyclosporin.…”

mentioning

confidence: 99%

Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid

Saeki¹,

Watanabe²,

Tada³

et al. 2008

The Journal of Dermatology

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Generalized pustular psoriasis precipitated by topical calcipotriol ointment

Cited by 12 publications

References 6 publications

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Japanese guidelines for the management and treatment of generalized pustular psoriasis: The new pathogenesis and treatment of GPP

Acrodermatitis continua of Hallopeau on toes successfully treated with a two‐compound product containing calcipotriol and betamethasone dipropionate

Juvenile pustular psoriasis associated with steroid withdrawal syndrome due to topical corticosteroid

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