Generalized pustular figurate erythema: A newly delineated severe cutaneous drug reaction linked with hydroxychloroquine

Schwartz, Robert A.; Jänniger, Camila K.

doi:10.1111/dth.13380

Cited by 57 publications

(74 citation statements)

References 24 publications

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“…In the last case, oral lesions affected both keratinized and non-keratinized tissue and were more compatible with an erythema multiforme (Trayes, Love, & Studdiford, 2019;Schwartz & Janniger, 2020).…”

Section: F I G U R Ementioning

confidence: 99%

Oral vesiculobullous lesions associated with SARS‐CoV‐2 infection

et al. 2020

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Section: F I G U R Ementioning

confidence: 99%

Oral vesiculobullous lesions associated with SARS‐CoV‐2 infection

et al. 2020

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“…The skin signs of COVID-19 are being elucidated, 25,28,29 including those of a possible life-threatening drug reaction to hydroxychloroquine therapy called generalized pustular figurate erythema. 30 High population densities, poor hygiene, migration, and international travels contribute substantially to both pandemics. 5,[23][24][25]31 There is much to be learned.…”

Section: In a Large Study From The Walter Reed Army Medical Center Sumentioning

confidence: 99%

Cutaneous manifestations of a 21st century worldwide fungal epidemic possibly complicating the COVID ‐19 pandemic to jointly menace mankind

Schwartz

Kapila

2020

Dermatologic Therapy

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In view of the new viral COVID‐19 pandemic, the fungal Candida auris epidemic still in progress worldwide highlights non‐Candida albicans candidal infections. We describe an immunocompetent woman with a cutaneous manifestation of Candida parasilopsis fungemia, a prominent eschar, which proved to be the nidus for the candidemia. We stress the value of selectively removing eschars. C. parasilopsis and C. auris are increasingly important causes of sepsis and wound infections. We emphasize that commercially available biochemical‐based tests may misidentify C. auris as C. parapsilosis, and stress the added danger of C. auris to critically ill‐hospitalized COVID‐19 patients. Any health care facility with evidence of infection or colonization with C. auris requires very close monitoring, since this fungus is a nosocomial threat comparable to SARS‐CoV‐2 in its mortality and fomite adhesiveness! Both organisms have the potential to be transmitted as nosocomial pathogens; health care workers need to follow strict CDC guidelines. During this COVID‐19 pandemic, every health care facility should closely monitor for the possible deadly combination of the SARS‐CoV‐2 and C. auris. The identification of C. auris necessitates use of sophisticated technology not readily available to make this essential diagnosis since C. auris is multi‐drug resistant and isolation precautions would become paramount.

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“…An atypical form of AGEP, generalized pustular figurate erythema, has been described as a delayed reaction to HCQ. 9 Nevertheless, the incidence of this adverse effect to HCQ is infrequent. 10 Thus, if the type of exanthema we are describing here is related to HCQ, there may be another factors (as SARS-CoV-2 virus itself) playing a role.…”

mentioning

confidence: 99%