Generalized prepubertal periodontitis

Abstract

The clinical and immunological data from 4 patients with generalized prepubertal periodontitis are presented. The peripheral blood neutrophil chemotaxis was measured using zymosan activated sera as the chemoattractant. All of the 4 patients have shown depressed neutrophil chemotaxis compared to those of the healthy controls. Peripheral blood lymphocyte subpopulations were analysed by double-coloured flow cytometry using monoclonal antibodies for the receptors CD2, CD3, CD4, CD8, CD19, CD29, CD45RA+, 34,29dK, CD56. CD11b/CD18. Lymphocytes bearing CD3 receptors showed a significant decrease compared to those of the controls. Natural killer cells were lowered in 3 of the 4 cases. All of the patients showed a higher increase in CD11b/CD18 expression. The evaluation of CD11b/CD18 receptor in peripheral blood leukocytes may be of help explaining the rôle of neutrophils in the pathogenesis of the disease.

Papillon‐Lefèvre Syndrome. Analysis of Neutrophil Chemotaxis

“…43-48-50 It was observed that neutrophils were normal in patients with Papillon-Lefèvre syndrome.24-33 Contrary to these findings in most of the studies with the patients with PLS, the peripheral blood neutrophil Chemotaxis was depressed.162226-34 The decrease in the Chemotaxis may be due to a cell defect in the receptor located at the surface of the neutrophil.50 It has been reported that the Chemotaxis defect might be the result of deficiencies in the cellular adhesion molecules.26-50-52 Another suggested cause was an abnormality in cell adhesion which resulted from abnormalities on CDU molecules in children with generalized prepubertal Periodontitis. [2][3][4][5] In this study, we found that the Chemotaxis of neutrophils in PLS patients decreased compared to healthy controls. The neutrophil Chemotaxis defect in patients with PLS is characterized by a decrease in the cell migration toward a chemotactic factor (ZAS).…”

The Role of Activated Cytotoxic T Cells in Etiopathogenesis of Periodontal Disease: Does It Harm or Does It Heal?

“…Our results indicated that there is a significant increase in activated cytotoxic T cells in both GAgP and CP patients compared to HC. Several studies examined the CD8 + cytotoxic T cells but did not identify whether these cells were activated 13 22 27 . To the best of our knowledge none of the previous studies have mentioned about the involvement of activated cytotoxic T cells as a contributing factor to the pathogenesis of periodontitis.…”

“…Considerable number of reports have been accumulated since the 1980s that have aimed at looking at the immunological profiles of the periodontitis cases using different techniques such as immunohistochemistry and flow cytometry 20 21 22 23 24 . However, in such studies immune system was regarded as the “healing” factor.…”

The Influence of Surgical Treatment of Periodontal Disease on Selected Lymphocyte Subpopulations Important for Cellular and Humoral Immune Responses

“…Moreover, Firatli et al observed lower CD3+ T percentages in four patients with generalized prepubertal periodontitis than in controls. 19 Other authors have conflicting observations of the CD4/CD8 ratio in patients with periodontitis. Results similar to our study were observed by Takahashi et al in a case report of a patient with early-onset periodontitis.…”