Generalized Muscular Stiffness, Fasciculations, and Myokymia of Peripheral Nerve Origin

Wallis, William; Poznak, Alan Van; Plum, Fred

doi:10.1001/archneur.1970.00480230048005

Cited by 116 publications

(32 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The similarities concerned the essential charac teristics of Isaacs's syndrome, such as gener alized muscular contractions, fasciculations, hyperhydrosis, and continuous electromyographical activity at rest. The differences consisted in: (a) diffuse muscular atrophies; (b) tendon hyperreflexia, reported also by Cusumano et al [3]; (c) absence of plantar reflexes; (d) slowing down o f motor conduc tion velocity, reported also by Buscaino et al [2], Irani et al [5], Lublin et al [8] and Wallis et al (9]; (0 marked and diffuse denervation atrophy at histological examination o f mus cular biopsy, reported also, but in a more dis crete form, by Buscaino et al [2], Welch et al [10] and Barron et al [1], and (g) insufficient response to diphenylhydantoin and/or carbamazepinc, reported also by Wallis et al [9] and Barron et al [ 1 ].…”

Section: Discussionmentioning

confidence: 92%

Continuous Muscle Fiber Activity Associated with Denervation Atrophy

et al. 1982

View full text Add to dashboard Cite

We describe a case presenting continuous muscle fiber activity syndrome, which was slightly reduced by the blocking of nerve conduction and abolished by ischemia. Clinical, electromyographical and bioptical evidence of marked abnormalities of peripheral motoneurons were observed. Association with central motoneuron lesions was suspected due to the observation of initial pyramidal signs. Therapy with diphenylhydantoin and/or carbamazepine resulted only in discrete amelioration of the syndrome. This case, which presented similarities as well as differences to the cases described by Isaacs and to those reported by other authors after 1961, stimulates a critical discussion of the already raised problem of the clinical heterogeneity of continuous muscle fiber activity syndrome.

show abstract

Section: Discussionmentioning

confidence: 92%

Continuous Muscle Fiber Activity Associated with Denervation Atrophy

et al. 1982

View full text Add to dashboard Cite

show abstract

“…Lance et al [7] prefer the term neuromyotonia which appears to be 'the simplest and most appropriate to describe this syndrome'. A similar inherited syndrome with continuous motor neuron dis charges is also well described [9], Neuromyo tonia originating in motor axons has been documented following exposure to the herbi cide dichlorophenoxy-acctic acid [ 10], Recently, it has been suggested that muscle hyperactivity may also be due to a partial loss of motor innervation, compensated by collat eral sprouting of surviving axons. This may be seen in association with certain peripheral neuropathies, both axonal and demyelinative [11].…”

Section: Discussionmentioning

confidence: 93%

Neurogenic Benign Muscle Fasciculations

Ravindran¹

1994

Med Princ Pract

View full text Add to dashboard Cite

show abstract

“…However, it is noteworthy that myalgia is a relatively common adverse reaction to bumetanide as it is to frusemide (Cuthbert, 1975) and that muscle stiffness also occurs frequently after bumetanide (Berg, Tromsdal & Wider0e, 1975). Therefore, apart from the acute manifestation of myotonia, the myopathies and neuropathies resulting from chronic exposure to myotonic agents (RUdiger et al, 1972;Prescott et al, 1979;Wallis, Poznak, Plum, 1970) require consideration. Indeed, the frequent association of dystrophy with myotonia, also in the hereditary myotonias, begs the question of whether there is any casual relationship (Bryant, 1977).…”

Section: Discussionmentioning

confidence: 99%

Myotonia as a Side Effect of Diuretic Action

Bretag

Dawe

Kerr

et al. 1980

British J Pharmacology

View full text Add to dashboard Cite

1 Commonly used loop diuretics produce side effects in man which are similar to chemically induced myotonia. These diuretics have structural affinity with known myotonic agents. 2 We have observed EMG myotonia in vivo in leg muscles of rats treated with intravenous frusemide. 3 In the presence of several different diuretics, rat isolated diaphragm, soleus and extensor digitorum longus muscles as well as frog sartorius muscles produce typically myotonic contractions with relaxation times up to several seconds. 4 Intracellular recording of action potentials from diuretic-treated muscles reveals long lasting after-discharges following a brief electrical stimulus, again typical of chemically induced myotonia. 5Having demonstrated a myotonic action of several diuretics we suggest a need for caution in using these drugs in persons with hereditary myotonia and a need to be aware of possible provocation of myotonia in subclinical cases. Myopathies and neuropathies which are known to result from chronic exposure to myotonic agents also need to be considered. 6 In our study, the diuretic, acetazolamide, unmasked subthreshold myotonia. This seems to be at variance with reports of its usefulness in the treatment of myotonia. 7 Diuretics should probably not be employed in the treatment of herbicide intoxication where their myotonic activity would be expected to add to the known myotonic activity of the herbicide.

show abstract

Generalized Muscular Stiffness, Fasciculations, and Myokymia of Peripheral Nerve Origin

Cited by 116 publications

References 21 publications

Continuous Muscle Fiber Activity Associated with Denervation Atrophy

Continuous Muscle Fiber Activity Associated with Denervation Atrophy

Neurogenic Benign Muscle Fasciculations

Myotonia as a Side Effect of Diuretic Action

Contact Info

Product

Resources

About