Generalized muscular steatosis (pseudohypertrophy) in a heifer

Ohfuji, S.

doi:10.1007/s00580-013-1723-7

Cited by 4 publications

(5 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…6,41 In certain other breeds of cattle, extensive replacement of muscle by well-differentiated mature white adipocytes, small numbers of degenerating, necrotic, or atrophic myocytes, little evidence of regenerating myocytes, and minimal proliferation or thickening of the perimysial connective tissue have been reported. 39,40 At a cellular level, these findings essentially mirror what occurs in Asnsd1 −/− mice. However, unlike our mice, only a few muscle groups are affected in cattle, and they also typically developed marked hepatic steatosis.…”

Section: Discussionsupporting

confidence: 61%

“…The degenerative myopathy with extensive replacement of myocytes by adipocytes in Asnsd1 −/− mice is similar to conditions known as muscular steatosis or lipomatous myopathy, which have been reported as sporadic findings in cattle, pigs, sheep, horses and dogs. 6,39,40 For example, in the lipomatous myopathy affecting Piedmontese cattle, the degenerative myopathy is characterized by variations in fiber size, internalized nuclei, fiber necrosis, macrophage invasion, and finally the replacement of degenerating muscle cells by adipocytes. 6,41 In certain other breeds of cattle, extensive replacement of muscle by well-differentiated mature white adipocytes, small numbers of degenerating, necrotic, or atrophic myocytes, little evidence of regenerating myocytes, and minimal proliferation or thickening of the perimysial connective tissue have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…However, unlike our mice, only a few muscle groups are affected in cattle, and they also typically developed marked hepatic steatosis. 39,40…”

Section: Discussionmentioning

confidence: 99%

“…However, unlike our mice, only a few muscle groups are affected in cattle, and they also typically developed marked hepatic steatosis. 39,40 The cause of the moderately reduced viability of Asnsd1 À/À mice at weaning was not determined, but it may be related to seizures, which were observed in approximately half of Asnsd1 À/À mice from 3 to 12 months of age and were associated with handling. Evaluation of brain and spinal cord sections and blood chemistry data failed to identify an obvious cause for the seizures.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Progressive Degenerative Myopathy and Myosteatosis in ASNSD1-Deficient Mice

et al. 2020

View full text Add to dashboard Cite

Mice with an inactivating mutation in the gene encoding asparagine synthetase domain containing 1 (ASNSD1) develop a progressive degenerative myopathy that results in severe sarcopenia and myosteatosis. ASNSD1 is conserved across many species, and whole body gene expression surveys show maximal expression levels of ASNSD1 in skeletal muscle. However, potential functions of this protein have not been previously reported. Asnsd1−/− mice demonstrated severe muscle weakness, and their normalized body fat percentage on both normal chow and high fat diets was greater than 2 SD above the mean for 3651 chow-fed and 2463 high-fat-diet–fed knockout (KO) lines tested. Histologic lesions were essentially limited to the muscle and were characterized by a progressive degenerative myopathy with extensive transdifferentiation and replacement of muscle by well-differentiated adipose tissue. There was minimal inflammation, fibrosis, and muscle regeneration associated with this myopathy. In addition, the absence of any signs of lipotoxicity in Asnsd1−/− mice despite their extremely elevated body fat percentage and low muscle mass suggests a role for metabolic dysfunctions in the development of this phenotype. Asnsd1−/− mice provide the first insight into the function of this protein, and this mouse model could prove useful in elucidating fundamental metabolic interactions between skeletal muscle and adipose tissue.

show abstract

Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

“…However, unlike our mice, only a few muscle groups are affected in cattle, and they also typically developed marked hepatic steatosis. 39,40…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Progressive Degenerative Myopathy and Myosteatosis in ASNSD1-Deficient Mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…In this regard, muscle presented the features aforementioned; however, heart and kidney presented an overstored triglycerides, precisely in relation to low capacity of energetic spend promoted by insulin administration, in contrast with liver which had no difference between groups. This apparent discordance between ideas is in relation to insulin which stimulates intracellular triglyceride synthesis while inhibiting lipolysis in tissues with low energy obtained by lipids [ 53 – 55 ].…”

Section: Discussionmentioning

confidence: 99%

Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus

Treviño

Velázquez-Vázquez

Sánchez-Lara

et al. 2016

Oxidative Medicine and Cellular Longevity

View full text Add to dashboard Cite

New potential drugs based on vanadium are being developed as possible treatments for diabetes mellitus (DM) and its complications. In this regard, our working group developed metforminium decavanadate (MetfDeca), a compound with hypoglycemic and hypolipidemic properties. MetfDeca was evaluated in models of type 1 and type 2 diabetes mellitus, on male Wistar rats. Alloxan-induction was employed to produce DM1 model, while a hypercaloric-diet was employed to generate DM2 model. Two-month treatments with 3.7 μg (2.5 μM)/300 g/twice a week for DM2 and 7.18 μg (4.8 μM)/300 g/twice a week for DM1 of MetfDeca, respectively, were administered. The resulting pharmacological data showed nontoxicological effects on liver and kidney. At the same time, MetfDeca showed an improvement of carbohydrates and lipids in tissues and serum. MetfDeca treatment was better than the monotherapies with metformin for DM2 and insulin for DM1. Additionally, MetfDeca showed a protective effect on pancreatic beta cells of DM1 rats, suggesting a possible regeneration of these cells, since they recovered their insulin levels. Therefore, MetfDeca could be considered not only as an insulin-mimetic agent, but also as an insulin-enhancing agent. Efforts to elucidate the mechanism of action of this compound are now in progress.

show abstract

Pathology of muscular steatosis in the bovine species: report of two spontaneously arising cases and comparative overview of the condition

Ohfuji¹

2016

Comp Clin Pathol

View full text Add to dashboard Cite

Generalized muscular steatosis (pseudohypertrophy) in a heifer

Cited by 4 publications

References 8 publications

Progressive Degenerative Myopathy and Myosteatosis in ASNSD1-Deficient Mice

Progressive Degenerative Myopathy and Myosteatosis in ASNSD1-Deficient Mice

Metforminium Decavanadate as a Potential Metallopharmaceutical Drug for the Treatment of Diabetes Mellitus

Pathology of muscular steatosis in the bovine species: report of two spontaneously arising cases and comparative overview of the condition

Contact Info

Product

Resources

About