Generalized morphea following radiotherapy for an intracranial tumor

Balegar, Shrenik; Mishra, Dharmendra Kumar; Chatterjee, Sagarika; Kumari, Shweta; Tiwary, Anup Kumar

doi:10.4103/0019-5154.190132

Cited by 7 publications

(5 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In 2017, Caccavale, Caccavale, and La Montagna () analyzed the clinical case, reported by Balegar, Mishra, Chatterjee, Kumari, and Tiwary (), of a 27‐year‐old male who developed radiation‐induced morphea, arising in previously irradiated area, some months after the last cycle of radiotherapy for an intracranial tumor.…”

Section: Discussionmentioning

confidence: 99%

Isoradiotopic response of discoid lupus after radiotherapy: A case report and review of the literature

Carlesimo

Pigliacelli

D’Arino

et al. 2019

Dermatologic Therapy

View full text Add to dashboard Cite

Radiotherapy is frequently associated with a great number of collateral effects, which can affect the skin and its appendages. In addition to more common side effects, like radiodermatitis, other cutaneous conditions are less known and often they are underdiagnosed. Among these, isoradiotopic response is one of the rare radiotherapy-associated phenomena. This term refers to the appearance of a secondary dermatosis in a previously irradiated district. The term was used for the first time by Shurman et al. to describe a case of lichen ruber planus arising in the

show abstract

Section: Discussionmentioning

confidence: 99%

Isoradiotopic response of discoid lupus after radiotherapy: A case report and review of the literature

Carlesimo

Pigliacelli

D’Arino

et al. 2019

Dermatologic Therapy

View full text Add to dashboard Cite

show abstract

“…RIM generally occurs within the radiation field but rarer cases demonstrate involvement beyond the treated area ( Akay et al, 2010 , Spalek et al, 2015 ). There are a few reported cases of distant site morphea in response to radiation therapy ( Ardern-Jones and Black, 2003 , Balegar et al, 2016 ). One case of endometrial cancer that was treated with brachytherapy and external beam radiation therapy featured lesions that extended from the site of treatment to the right lower abdomen and the upper and lower leg ( Akay et al, 2010 ).…”

Section: Discussionmentioning

confidence: 99%

Radiation-induced circumscribed superficial morphea after brachytherapy for endometrial adenocarcinoma

Trivedi

DeWitt

McGevna

2017

International Journal of Women's Dermatology

View full text Add to dashboard Cite

Radiation-induced morphea (RIM) is a rare and underrecognized complication of radiation therapy that most commonly occurs in women after treatment for breast cancer. Although not fully understood, RIM is hypothesized to arise from an increase in cytokines that stimulate collagen production and extracellular matrix formation. Most documented cases of RIM occur 1 year after radiation therapy and are localized to areas that were treated for breast cancer. We report on a case of a female patient with stage IB endometrial adenocarcinoma who was treated with 24 Gray of adjuvant brachytherapy. The patient developed a diffuse morpheaform, pruritic eruption only at distant sites from the brachytherapy treatment field. Although treatment for RIM is generally unsatisfactory, our patient experienced improvement in the pruritus and a regression of the lesions while applying topical 0.1% tacrolimus ointment and 0.1% triamcinolone creme. An early diagnosis of RIM can prevent extensive workup, guide treatment, and improve quality of life for patients.

show abstract

“…I am delighted that authors have shown keen interest in the case report published in the journal. [ 1 ] Radiation in our case definitely caused alteration in the local immune response the so-called “immunocompromised cutaneous district,” which led to the development of morphea. The authors have thrown light on the mechanism, by which immune dysregulation occurs in the irradiated areas.…”

mentioning

confidence: 82%