Generalized Lymphogranulomatosis of the Skin

Jones, Jack W.; Alden, Herbert S.

doi:10.1001/archderm.1929.01440020064011

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“…[ 6 ] Similarly, a case of alopecia of scalp followed by total body alopecia was reported by Jones and Alden. [ 7 ] Cases of alopecia areata and telogen effluvium occurring concomitantly with Hodgkin's disease have been reported. [ 3 8 9 ]…”

Section: Discussionmentioning

confidence: 99%

Hodgkin′s lymphoma presenting as alopecia

et al. 2012

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Alopecia is a rare manifestation of Hodgkin's disease. It may be due to follicular destruction due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. In this patient, hair loss, diffuse yperpigmentation, and generalized itching preceded other manifestations of the disease. The pattern of hair loss was diffuse and generalized in nature involving scalp, eyebrows, axilla, and groin. Subsequently, the patient was diagnosed to be a case of Hodgkin's lymphoma, based on clinical and histopathological features. Earlier reports on alopecia accompanying Hodgkin's disease have also been discussed. This case highlights the importance of keeping a high suspicion of an underlying malignancy in patients presenting with such cutaneous manifestations.

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