Generalized Lichen Nitidus in Identical Twins

Leung, Alexander K. C.; Ng, Jeffrey

doi:10.1155/2012/982084

Cited by 6 publications

(8 citation statements)

References 6 publications

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“…Unfortunately, no data were available about the hepatitis B vaccination status of our cohort. Generalized LN was specified in 41% of patients, which is a higher than expected incidence . This difference might be due to the inclusion of biopsy‐proven cases since arguably, skin biopsy would be more likely performed in LN patients with widespread or more severe involvement.…”

Section: Discussionmentioning

confidence: 90%

“…Generalized LN was specified in 41% of patients, which is a higher than expected incidence. 1,5,13,14 This difference might be due to the inclusion of biopsy-proven cases since arguably, skin biopsy 2,17,18 Although LN and lichen planus have similar ultrastructural findings, immunofluorescent studies suggest certain differences. 16 As noted previously, seven of 17 had comorbid skin conditions.…”

Section: Discussionmentioning

confidence: 99%

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Pediatric lichen nitidus: A single‐center experience

Kundak

Çakır

2019

Pediatric Dermatology

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Objective Lichen nitidus (LN) is an uncommon inflammatory skin eruption. The present study aims to describe a case series of children with LN seen at a tertiary‐care health center. Methods Retrospective study of 17 children with biopsy‐proven LN between January 2007 and March 2017. Data related with epidemiologic, clinical, and histopathologic characteristics were recorded. Results The mean age for the onset of LN was 9 years (range: 5‐17 years), and the mean duration of the skin lesions was 13 months (range: 1‐48 months). Fifteen were boys (88.2%). Seven children had a generalized form of LN (41.1%) and of these, two children had severe pruritus (11.8%). Seven children had a history of co‐morbid skin conditions (41.1%), including lichen planus in one patient (5.9%), lichen striatus in one patient (5.9%), psoriasis and longitudinal ridges in the nails in one patient (5.9%), and cutaneous features of atopic skin in four patients (23.5%). All of the reviewed patients had lymphohistiocytic infiltration in the dermis and basal vacuolar degeneration. Multinucleated giant cells were present in 11 (64.7%). Conclusion This case series found LN in a generalized form as well as other concurrent dermatologic conditions in nearly half of those reported. The boy predominance was also noteworthy.

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Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Pediatric lichen nitidus: A single‐center experience

Kundak

Çakır

2019

Pediatric Dermatology

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“…Lichen nitidus is a chronic inflammatory dermatosis characterized by numerous, asymptomatic, discrete, flat-topped, flesh-colored, shiny, pinhead- to pinpoint-sized papules (Figure 11). 43,44 The abdomen, chest, extremities, and penis are sites of predilection 43–45. The lesions are usually arranged in groups 43…”

Section: Diagnosismentioning

confidence: 99%

“…These modalities of treatment have the highest success rate but also have the potential of leaving scars on the skin. Topical anesthesia, such as with Nanorap (a hydrogel with 2.5% lidocaine and 2.5% prilocaine with 50% of active products in nanocapsules) applied over the lesions without occlusion 20 minutes before the procedure or a eutectic mixture of local anesthetics (EMLA) applied over the lesions with occlusion for an hour before the procedure, should be considered to reduce the discomfort/pain, which can be disturbing for some individuals 44. General anesthesia may be necessary for surgical removal of large and extensive lesions.…”

Section: Managementmentioning

confidence: 99%

Penile warts: an update on their evaluation and management

Leung¹,

Barankin²,

Leong³

et al. 2018

DIC

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BackgroundPenile warts are the most common sexually transmitted disease in males. Clinicians should be familiar with the proper evaluation and management of this common condition.ObjectiveTo provide an update on the current understanding, evaluation, and management of penile warts.MethodsA PubMed search was completed in Clinical Queries using the key terms ‘penile warts’ and ‘genital warts’. The search strategy included meta-analyses, randomized controlled trials, clinical trials, observational studies, and reviews.ResultsPenile warts are caused by human papillomavirus (HPV), notably HPV-6 and HPV-11. Penile warts typically present as asymptomatic papules or plaques. Lesions may be filiform, exophytic, papillomatous, verrucous, hyperkeratotic, cerebriform, fungating, or cauliflower-like. Approximately one-third of penile warts regress without treatment and the average duration prior to resolution is approximately 9 months. Active treatment is preferable to watchful observation to speed up clearance of the lesions and to assuage fears of transmission and autoinoculation. Patient-administered therapies include podofilox (0.5%) solution or gel, imiquimod 3.75 or 5% cream, and sinecatechins (polypheron E) 15% ointment. Clinician-administered therapies include podophyllin, cryotherapy, bichloroacetic or trichloroacetic acid, oral cimetidine, surgical excision, electrocautery, and carbon dioxide laser therapy. Patients who do not respond to first-line treatments may respond to other therapies or a combination of treatment modalities. Second-line therapies include topical/intralesional/intravenous cidofovir, topical 5-fluorouracil, and topical ingenol mebutate.ConclusionNo single treatment has been shown to be consistently superior to other treatment modalities. The choice of the treatment method should depend on the physician’s comfort level with the various treatment options, the patient’s preference and tolerability of treatment, and the number and severity of lesions. The comparative efficacy, ease of administration, adverse effects, cost, and availability of the treatment modality should also be taken into consideration.

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“…The hypothesis is based on cases in which lichen nitidus was familial [6]. Speculations have been made that the lesions may correlate with Crohn disease and Down syndrome and that they may appear after tattooing [3, 14, 15].…”

mentioning

confidence: 99%