Generalized Lichen Nitidus

Ocampo, Jorge; Torné, Ramón

doi:10.1111/j.1365-4362.1989.tb01313.x

Cited by 32 publications

(2 citation statements)

References 6 publications

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“…Lichen nitidus presents with tiny, monomorphous, lichenoid, mostly asymptomatic papules in regional or disseminated distribution that shows a pathognomonic histological pattern [ 65 ]. H-1 antihistamines such as astemizole [ 66 , 67 ] and cyproheptadine [ 68 ] have been reported to be beneficial in case reports of patients with generalized lichen nitidus. However, the propensity for the disease to resolve spontaneously makes it difficult to evaluate the true effectiveness of various therapies for this disease [ 69 ].…”

Section: Clinical Applications In Dermatologic Diseasesmentioning

confidence: 99%

Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review

Hsieh

Tsai

2021

Dermatol Ther (Heidelb)

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H-1 antihistamines are commonly used in dermatological practice for itch and urticaria control. The widespread expression of H-1 receptor on different cells in the skin and various biologic functions of H-1 antihistamines indicate the possible treatment potentials of H-1 antihistamines in dermatology. A literature search was performed on PubMed and Embase, targeting articles reporting use of antihistamine for purposes other than itch and urticaria control in dermatological practice. Several off-label usages of antihistamines were identified, including alopecia, acne, Darier disease, eosinophilic dermatoses, paraneoplastic dermatoses, psoriasis, lichen nitidus, radiation dermatitis, skin dysesthesia, and cutaneous malignancies. Additional benefits were observed when H-1 antihistamines were used either alone or in combination with other therapeutic modalities. Although various novel uses of H-1 antihistamines have been uncovered, the evidence level of most included studies is weak. Further randomized control trials are warranted to better evaluate the efficacy and dosage of H-1 antihistamine for dermatological disorders.

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Section: Clinical Applications In Dermatologic Diseasesmentioning

confidence: 99%

Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review

Hsieh

Tsai

2021

Dermatol Ther (Heidelb)

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“…However, medical treatment is required when the lesions are persistant, generalized, and when they are considered cosmetically undesirable or accompanied by symptoms such as pruritus. Many therapeutic modalities including topical and systemic corticosteroid, PUVA (2), ultraviolet A/ultraviolet B (UVA/UVB) with systemic corticosteroid (3), dinitrochlorobenzene (DNCB) or diphenylcyclopropenone immunotherapy (4), selective H1 antagonist (5), and even itraconazole (6) and isoniazide (7) have been used to treat LN patients. Especially, PUVA therapy and astemizole have been effective for generalized LN, whereas acitretin demonstrated a reduction in the palmoplantar forms (8).…”

Section: Discussionmentioning

confidence: 99%

Generalized Lichen Nitidus Successfully Treated with Narrow-band UVB Phototherapy : Two Cases Report

Kim

et al. 2007

J Korean Med Sci

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Lichen nitidus (LN) is an uncommon chronic inflammatory skin disease composed of numerous, tiny, shiny, flesh-colored papules that are predominantly observed on the chest, abdomen, glans penis and upper extremities. The distribution of LN is most often localized, but in some cases it can become generalized. Because LN tends to be asymptomatic and presents spontaneous resolution within several years, it usually does not require treatment except in symptomatic, persistent and generalized cases. We describe a 28-yr-old man and a 7-yr-old boy with generalized LN where both cases improved with narrow-band ultraviolet B (NB-UVB) phototherapy plus topical steroid ointment. Both patients noted improvement within the first three treatments and showed almost complete resolution after 18 and 20 treatments, respectively. NB-UVB phototherapy may be an effective alternative therapy for the treatment of generalized LN, even for those patients in their childhood.

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Lichen Planus and Lichenoid Disorders

Breathnach¹,

Black²

2004

Rook's Textbook of Dermatology

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Generalized Lichen Nitidus

Cited by 32 publications

References 6 publications

Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review

Use of H-1 Antihistamine in Dermatology: More than Itch and Urticaria Control: A Systematic Review

Generalized Lichen Nitidus Successfully Treated with Narrow-band UVB Phototherapy : Two Cases Report

Lichen Planus and Lichenoid Disorders

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