Generalized hypertrichosis associated with the use of interleukin 17 blockers in 2 patients with psoriasis

Sánchez-Dueñas, Luis Enrique; Rojano-Fritz, Lizet K.; Garcia-Rodriguez, Juan C.

doi:10.1016/j.jdcr.2020.05.023

Cited by 4 publications

(7 citation statements)

References 9 publications

(14 reference statements)

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“…This could point towards a relationship between IL-17 and HF cycling. Indeed, conflicting reports of psoriatic patients undergoing IL-17-neutralizing treatments show that they frequently develop either hypertrichosis or alopecia (e.g., excessive hair growth or loss, respectively), pointing out that blocking an excessive IL-17 signaling could influence hair follicle cycling in humans 81,82 . On the other hand, the excessive IL-17 signaling observed in aged dermal cells might underlie the development of bullous pemphigoid, an autoimmune disorder with aberrant IL-17 signaling that is characterized by skin blistering, and whose incidence is increased in elderly people 53 .…”

Section: Discussionmentioning

confidence: 99%

Local IL-17 orchestrates skin aging

Solá

Mereu

Bonjoch

et al. 2022

Preprint

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Skin aging is characterized by structural and functional changes that lead to slower wound healing and higher rate of infections, which contribute to age-associated frailty. This likely depends on synergy between alterations in the local microenvironment and stem cell–intrinsic changes, underscored by pro-inflammatory microenvironments that drive pleotropic changes. To date, little is known about the precise nature and origin of the proposed age-associated inflammatory cues, or how they affect different tissue resident cell types. Based on deep single-cell RNA-sequencing of the entire dermal compartment, we now provide a comprehensive understanding of the age-associated changes in all skin cell types. We show a previously unreported skew towards an IL-17–expressing phenotype of Th cells, γδ T cells and innate lymphoid cells in aged skin. Aberrant IL-17 signaling is common to many autoimmune (e.g., rheumatoid arthritis and psoriasis) and chronic inflammatory diseases. Importantly, in vivo blockade of IL-17–triggered signaling during the aging process reduces the pro-inflammatory state by affecting immune and non-immune skin cells of both dermis and epidermis. Strikingly, IL-17 neutralization significantly delays the appearance of age-related traits, such as decreased epidermal thickness, increased cornified layer thickness and ameliorated hair follicle stem cell activation and hair shaft regeneration. Our results indicate that the aged skin shows chronic and persistent signs of inflammation, and that age-associated increased IL-17 signaling could be targeted as a strategy to prevent age-associated skin ailments in elderly.

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Section: Discussionmentioning

confidence: 99%

Local IL-17 orchestrates skin aging

Solá

Mereu

Bonjoch

et al. 2022

Preprint

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“…Hair changes including repigmentation or hypertrichosis were reported 1 to 6 months after initiation of treatment in four patients. Excess hair growth was not bothersome to the fifth and was identified in a routine visit 20 months after starting therapy 4 . Three patients developed generalized hypertrichosis most visible on the trunk and extremities 1,4 .…”

Section: Patient Age/sex Treatment Indication Il‐17 Inhibitor Psorias...mentioning

confidence: 98%

“…In the three cases with a reported outcome, the hair changes persisted at follow‐up 5, 6, and 10 months later (Table 1). 2‐4 …”

Section: Patient Age/sex Treatment Indication Il‐17 Inhibitor Psorias...mentioning

confidence: 99%

“…In the three cases with a reported outcome, the hair changes persisted at follow-up 5, 6, and 10 months later ( Table 1). [2][3][4] In adults, hypertrichosis is most commonly drug induced. 5 Among psoriatic patients treated with biologic therapy, isolated cases of hypertrichosis have been associated with efalizumab 6 and infliximab.…”

mentioning

confidence: 99%

“…All five reported patients to date were male with a median age of 62 (range 39-85) and moderate-to-severe psoriasis at baseline (Table 1). [1][2][3][4] Two patients had erythrodermic psoriasis, two had severe plaque psoriasis, and one had moderate recalcitrant psoriasis. Specific IL-17A inhibitors included secukinumab in four patients and ixekizumab in one.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Hypertrichosis and hair repigmentation in patients receiving interleukin‐17A inhibitors

Antoury

Maloney

Cheng

2020

Dermatologic Therapy

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Acquired Disorders of Hair

Harries,

Holmes,

McMichael

et al. 2024

Rook's Textbook of Dermatology

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This chapter reviews acquired hair disorders, including common scarring and non‐scarring alopecia presentations, conditions characterised by excessive body hair growth and acquired hair shaft disorders. We also describe the biology of normal hair follicles, including structure, hair cycle control and immunity, to better understand the mechanisms underlying these conditions. We present methods for clinical assessment, recommended investigation and management of each disease, and present summaries of frequently used therapeutics and cosmetic options employed when treating these problems.

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Generalized hypertrichosis associated with the use of interleukin 17 blockers in 2 patients with psoriasis

Cited by 4 publications

References 9 publications

Local IL-17 orchestrates skin aging

Local IL-17 orchestrates skin aging

Hypertrichosis and hair repigmentation in patients receiving interleukin‐17A inhibitors

Acquired Disorders of Hair

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