Generalized gingival enlargement due to accumulation of amyloid‐like material

Abstract

Hyaline or amyloid-like substances may be seen in several oral lesions. Some of these originate from epithelial cells and some from connective tissue components. In this study, amyloid-like material causing gingival enlargement in three patients, with eyelid involvement in two, was examined using histochemistry, immunohistochemistry and electron microscopy. These accumulations did not share the classical features of amyloid such as green birefringence under polarized light after Congo red staining. Our findings suggest that epithelial degeneration plays an important role in the pathogenesis of these amyloid-like accumulations. These substances may be the result of defective amyloidogenesis and our cases may represent an oral counterpart of ligneous conjunctivitis or colloid milium of the skin.

Immunohistochemical analysis of the gingiva with periodontitis of type I plasminogen deficiency compared to gingiva with gingivitis and periodontitis and healthy gingiva

“…Ligneous lesions of the oral mucosa have been histopathologically described extensively (El Darouti, Zayed, El Kamah, & Mostafa, 2009; Gokbuget et al, 1997;Gunhan et al, 1994;Gunhan, Avci, Dereci, Akgun, & Celasun, 2012;Scully et al, 2001Scully et al, , 2007. According to this, gingival tissues from the 8 patients in our report were examined and diagnosed with ligneous periodontitis.…”

“…Pseudomembraneous disease is a rare inherited chronic inflammatory disease causing the clinical appearance of firm, massive, nodular, pseudomembraneous mucosal masses (Gokbuget et al, 1997;Gunhan et al, 1994;Gunhan, Gunhan, Berker, Gurgan, & Yildirim, 1999;Mingers, Heimburger, Zeitler, Kreth, & Schuster, 1997;Schuster, Hugle, & Tefs, 2007;Schuster & Seregard, 2003;Scully et al, 2001;Scully, Gokbuget, & Kurtulus, 2007). In the oral cavity these lesions appear as massive, painless ulcerated gingival enlargements covered with yellowish pseudomembranes without any tendency to bleed (Gokbuget et al, 1997;Gunhan et al, 1994;Kurtulus et al, 2007;Scully et al, 2001).…”

“…In the oral cavity these lesions appear as massive, painless ulcerated gingival enlargements covered with yellowish pseudomembranes without any tendency to bleed (Gokbuget et al, 1997;Gunhan et al, 1994;Kurtulus et al, 2007;Scully et al, 2001). There may be extensive bone loss adjacent to the gingival lesions (Gunhan et al, 1999;Kurtulus et al, 2007;Pantanowitz et al, 2004;Scully et al, 2001).…”

Destructive membranous periodontal disease (ligneous periodontitis): a case report and 3 years follow-up

“…4 The gingival lesions reported in association with this entity reveal that they were progressive and usually end with loss of teeth. [2][3][4]6 Several surgical and periodontal treatment efforts were unsuccessful in all the reported oral lesions. [2][3][4]6 In some cases, gingival lesions show regression or disappear following tooth loss, 3 but there is not any reported period for the regression of the lesions in the literature.…”

“…However, only a few of the reported cases of ligneous conjunctivitis have coexisted with oral and dermatological lesions. 3,4,6 Therefore, patients with destructive membranous lesions of the periodontal tissues should always be systemically evaluated and should be thoroughly examined for possible involvement of the skin and other mucosal surfaces. In the reported case, oral and eyelid lesions were seen together but there were not any dermatological lesions related with the disease.…”