Generalized eruptive histiocytoma: Pediatric case report and review of the published work

Takahashi, Saki; Muto, Jun; Takama, Hiroyuki; Yanagishita, Takeshi; Takeo, Tomohiro; Ohshima, Yuichiro; Watanabe, Daisuke

doi:10.1111/1346-8138.15005

Cited by 4 publications

(12 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[2][3][4][5][6] GEH is characterized by the presence of innumerable, red, firm, discrete macules and papules on the face, trunk, and arms. 2,7,8 Visceral involvement is not associated. 9 Histologically, the superficial dermis and mid dermis typically contain a nearly uniform infiltrate of histiocytes with a few lymphocytes and neutrophils.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Generalized Eruptive Histiocytoma With S100 Protein–Positive Histiocytes and Prominent Eosinophilic Infiltration: A Rare Case Report

Luo

Zhao²,

Zhang³

2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

Generalized eruptive histiocytoma (GEH) is a very rare benign disorder belonging to the group of non-Langerhans cell histiocytosis (non-LCH). GEH is characterized by a nearly uniform infiltrate of histiocytes with classic immunological phenotype (CD68 + , S-1002 and CD1a2). Prominent eosinophilic infiltration and S100positive histiocytes are rarely associated in GEH. In this article, we reported a middle-age man presented with disseminated reddish papules distributed on the trunk and proximal extremities. A skin biopsy of the papule showed a dense histiocytic infiltration with prominent eosinophils. By immunohistochemistry, the histiocytes revealed strongly positive for CD68 and S100 protein and negative for CD1a and Langerin (CD207). Based on clinical and histopathological criteria, the diagnosis of GEH was established. We presented this rare case of GEH with such distinctive features to strengthen the awareness of this uncommon form of non-LCH. Classical histopathological and immunological features cannot reliably distinguish GEH from other non-LCH.

show abstract

Section: Discussionmentioning

confidence: 99%

“…9 Histologically, the superficial dermis and mid dermis typically contain a nearly uniform infiltrate of histiocytes with a few lymphocytes and neutrophils. 2,8 The histiocytes usually stain positive for CD68, CD163, and factor XIIIa and negative for S100 protein, CD1a, and Langerin (Tables 1 and 2).…”

Section: Discussionmentioning

confidence: 99%

Generalized Eruptive Histiocytoma With S100 Protein–Positive Histiocytes and Prominent Eosinophilic Infiltration: A Rare Case Report

Luo

Zhao²,

Zhang³

2022

The American Journal of Dermatopathology

View full text Add to dashboard Cite

show abstract

“…Generalized eruptive histiocytosis (GEH) is a rare benign non‐Langherans cell hystiocytosis, with less than 30 cases reported to date in infants 1–3 . The eruption usually occurs before the age of 4 and is characterized by reddish to brownish papules symmetrically arranged on the trunk and extremities.…”

Section: Figurementioning

confidence: 99%

“…The eruption usually occurs before the age of 4 and is characterized by reddish to brownish papules symmetrically arranged on the trunk and extremities. Asymmetrical pattern of distribution and face involvement are very rare, and mucous membranes are always spared 1–5 . Lesions can increase in number for many years until spontaneous resolution.…”

Section: Figurementioning

confidence: 99%

“…Non-invasive imaging of a rare presentation of infantile generalized eruptive histiocytosis with xanthogranulomalike appearance: dermoscopy, reflectance confocal microscopy, and line-field optical coherence tomography Dear Editor, Generalized eruptive histiocytosis (GEH) is a rare benign non-Langherans cell hystiocytosis, with less than 30 cases reported to date in infants. [1][2][3] The eruption usually occurs before the age of 4 and is characterized by reddish to brownish papules symmetrically arranged on the trunk and extremities.…”

mentioning

confidence: 99%

See 1 more Smart Citation