Generalized edema with hypoproteinemia as initial presentation of celiac disease in a 3-year-old boy: case report

Ahel, Ivona Butorac; Dežulović, Mirna Šubat; Palčevski, Goran

doi:10.13112/pc.2015.27

Cited by 2 publications

(1 citation statement)

References 12 publications

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“…Along with that, children with CD like symptoms (group C) and children with DM1-CD (group D) were also observed. In the celiac groups, children showed hypoalbuminemia with the lowest level (2.7 g/dl) in group D. Albumin deficiencies among celiac patients have been described by many authors [ 22 , 23 ]. Newton and Singer in 2012 reported many metabolic deficiencies like iron, folates, and lower albumin levels in celiac patients and Tumay et al studied various parameters among different groups of children and observed lower levels of albumin, cholesterol, calcium, and hemoglobin [ 24 ].…”

Section: Discussionmentioning

confidence: 99%

Association of Serum Albumin, Globulin, and Transferrin Levels in Children of Poorly Managed Celiac Disease

Siddiqui

Uqaili

Memon

et al. 2023

BioMed Research International

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Background. Celiac disease (CD) is an autoimmune genetic disorder in which gluten protein causes inflammation of the intestinal enterocytes. CD diagnosis in most cases is delayed or mistreated due to its varied clinical features. We aimed to evaluate the protein profile imbalance in different CD groups of children, which could help aid in the diagnosis and proper management of the disease. Methodology. This was a cross-sectional study with a nonrandom purposive sampling technique. All samples were taken from tertiary care hospitals of Hyderabad, Pakistan. In total, there were 175 children (age 3-15 years) divided into five equal groups ( n = 35 ), namely, group A (control), group B (celiac diagnosed), group C (celiac-like symptoms), group D (celiac with type 1 diabetes mellitus), and group E (type 1 diabetes mellitus only). Clinical symptoms and laboratory parameters were analyzed among all the groups. Sera proteins, albumin, globulins, and transferrin levels were evaluated and compared with healthy individuals. Results. The albumin in serum of celiac groups B and C was 3.0 g/dl and 2.8 g/dl, respectively. While in diabetic patients with CD, it is 2.7 g/dl. The globulin levels were raised among all the celiac groups with typical GIT symptoms. The highest transferrin was observed in group B, celiac patients with severe anemia. Patients were not on GFD, hence had no or less recovery and had chronic symptoms of celiac. Conclusion. The misdiagnosis and poor management of celiac leads to chronic villous atrophy with imbalance in metabolic profile. Serum analysis of albumin, globulins, and transferrin may help in the diagnosis and proper management of the disease to recover the celiac symptoms.

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Section: Discussionmentioning

confidence: 99%

Association of Serum Albumin, Globulin, and Transferrin Levels in Children of Poorly Managed Celiac Disease

Siddiqui

Uqaili

Memon

et al. 2023

BioMed Research International

View full text Add to dashboard Cite

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Hypoalbuminemia and generalized edema as an atypical presentation of celiac disease

Meena

Kumar

Bohra

et al. 2020

J Family Med Prim Care

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Generalized edema with hypoproteinemia as initial presentation of celiac disease in a 3-year-old boy: case report

Abstract: Edema is defi ned as abnormal accumulation of fl uid in the interstitium

Cited by 2 publications

References 12 publications

Association of Serum Albumin, Globulin, and Transferrin Levels in Children of Poorly Managed Celiac Disease

Association of Serum Albumin, Globulin, and Transferrin Levels in Children of Poorly Managed Celiac Disease

Hypoalbuminemia and generalized edema as an atypical presentation of celiac disease

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