Generalized Eczematous Contact Dermatitis from Cocobolo Wood

Guanche, Anna D.; Prawer, S.

doi:10.1097/01634989-200306000-00008

Cited by 15 publications

(1 citation statement)

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“…Thus, the source of Nepalese propolis might be plants belonging to the genus Dalbergia . Neoflavonoids such as obtusaquinone, R -3,4-dimethoxydalbergione, R -4-methoxydalbergione, and other quinones isolated from Dalbergia species have been reported as allergens. − They are also reported to inhibit the growth of microorganisms, such as the marine borer Teredo navalis , and are reported to be useful in protective coatings on ships . As bees prepare propolis to protect their hive from foreign intruders, including microorganisms, these neoflavanoids may have a defensive role in protecting the hive.…”

Section: Resultsmentioning

confidence: 99%

Neoflavonoids and Related Constituents from Nepalese Propolis and Their Nitric Oxide Production Inhibitory Activity

Awale¹,

Shrestha²,

Tezuka³

et al. 2005

J. Nat. Prod.

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A methanolic extract of Nepalese propolis yielded 10 new open-chain neoflavonoids (1-10), a new chalcone (11), and eight previously reported compounds (12-19). Their structures were determined on the basis of spectroscopic data and chemical conversion. The isolated compounds other than 5, 8, and 16 showed dose-dependent inhibitory activities on nitric oxide production in lipopolysaccharide-activated macrophage-like J774.1 cells and were more active than a positive control, N(G)-monomethyl-L-arginine (IC(50), 27.1 microM). The most potent activities, of 6 and 7 (IC(50), 0.5 microM), were greater than another positive control, caffeic acid phenethyl ester (IC(50), 4.8 microM).

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Section: Resultsmentioning

confidence: 99%