Generalized dyspigmentation on the body

Abstract

A 20-year-old man presented to our clinic with progressive and asymptomatic mottled hyperpigmentation involving almost the whole of his body, which had been present since he was 8 years of age. The first lesions had appeared on the trunk and hyperpigmentation had extended gradually over the years to involve the neck, face and limbs. He had also noticed spotty hypopigmentation among the hyperpigmented macules.He did not have any inflammatory skin disease or systemic illness prior to the onset of the lesions. He reported similar skin changes in his father, sister and two brothers. Only one of his brothers was free of any lesions.On physical examination, areas of mottled hyperpigmentation and hypopigmentation with macules of varying sizes, ranging from 2 to 15 mm, were seen, involving almost the whole of the body (Fig. 1) in a symmetrical pattern with relative sparing of the hands and feet. Hair, nails, teeth, palms, soles and oral mucosae were normal. Systemic examination was unremarkable and routine blood investigations were normal. Histopathological findingsHistopathological examination of a skin biopsy from a pigmented macule revealed melanin incontinence. The number of melanocytes was normal. There was no collagen abnormality (Fig. 2).What is your diagnosis? C P D

Dyschromatosis symmetrica hereditaria: A case report from Turkey, a new association and a novel gene mutation

“…So, we examined his father in detail but there was no finding except a few slightly hyperpigmented macules on the extensor surfaces of his feet, although he described to us that he had had the same hyperpigmented macules on the hands and feet during his childhood but that they had disappeared over time. However, none of the previous studies reported seasonal changes or spontaneous regression with age 3 …”

“…To our knowledge, Aliağaoğlu et al. 3 reported the first Turkish patient that presented hyperpigmented and hypopigmented macules in a generalized distribution with dyschromatosis universalis hereditaria in 2008 3 …”