Generalized Cyclic Incomplete Block Designs

Jarrett, R. G.; Hall, W. B.

doi:10.2307/2335220

Cited by 10 publications

(16 citation statements)

References 11 publications

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“…A cyclic randomized incomplete block (Jarrett and Hall 1978) design with Intensity comprising the whole unit was super-imposed on a randomized complete block design of temperature and drug with trial as the subunit. Each trial was further divided into six time periods.…”

Section: Discussionmentioning

confidence: 99%

Hormonal responses to opioid receptor blockade: during rest and exercise in cold and hot environments

Armstrong

Hatfield

2006

Eur J Appl Physiol

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Opioid receptors appear to modulate a variety of physiological and metabolic homeostatic responses to stressors such as exercise and thermally extreme environments. To more accurately determine the role of the naloxone (NAL) sensitive opioid receptor system during rest and exercise, subjects were subjected to concomitant environmental thermal stress. Fifteen untrained men rested or performed low intensity (60% VO2peak) or high intensity (80% VO2peak) exercise on a cycle ergometer for 60 min in an environmental chamber during cold (0 degrees C) hot (35 degrees C) air exposure while receiving an infusion of normal saline (SAL) or NAL (0.1 mg kg(-1)). Plasma adrenocorticotropin hormone (ACTH), immunoreactive beta-endorphin (IBE), cortisol and growth hormone were measured at baseline and every 15 min while in the chamber. Time to exhaustion was significantly reduced during high intensity exercise in the heat (P<0.0001). NAL significantly (P=0.0004) reduced the time to exhaustion (38.3+/-2.1 min) during high intensity exercise in the heat compared to SAL (49.4+/-2.1 min). ACTH and IBE increased during hot conditions and cold attenuated this response. Plasma concentrations of IBE, ACTH, and growth hormone increased significantly with NAL during high intensity exercise in the heat compared to SAL. Cold attenuated the response of ACTH, IBE and cortisol to NAL. NAL administration exaggerates plasma hormone concentration during high intensity exercise in the heat, but not cold. These results support a regulatory effect of the opioid receptor system on physiological responses during exercise in thermally stressful environments. Future research should be directed to more clearly defining the effect of environmental temperature on the mechanism of hypothalamic-pituitary-adrenal hormonal release during exercise and hot environmental temperatures.

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Section: Discussionmentioning

confidence: 99%

Hormonal responses to opioid receptor blockade: during rest and exercise in cold and hot environments

Armstrong

Hatfield

2006

Eur J Appl Physiol

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“…The method used may be a direct matrix inversion, an iterative technique or that described by Jarrett & Hall (1978). The method used may be a direct matrix inversion, an iterative technique or that described by Jarrett & Hall (1978).…”

Section: Discussionmentioning

confidence: 99%

“…The generalized cyclic designs defined by Jarrett & Hall (1978) are particularly useful since as we show below their duals are also generalized cyclic designs. The monotone relationship between the efficiency factors of a design and its dual implies that a design has high efficiency factor if and only if its dual does.…”

Section: Construction and Methodsmentioning

confidence: 99%

“…The designs were generally constructed from the duals. In such situations, a search of possible generalized cyclic incomplete block designs (Jarrett & Hall, 1978) with a suitable incrementing number usually did reveal better designs. Tables A and B of John et al (1972) provided many suitable designs, designs for higher treatment numbers being found by a computer search in which the first initial block must be one of the equivalence classes; see, for example, David & Wolock (1965).…”

Section: Construction and Methodsmentioning

confidence: 99%

“…The designs given here are generalized cyclic incomplete block designs as defined by Jarrett & Hall (1978). They are often constructed as duals of designs of the same type with r > k. This method was used by Jarrett & Hall (1978) to construct designs for large treatment numbers as duals of cyclic incomplete block designs.…”

Section: Introductionmentioning

confidence: 99%

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Nonresolvable Incomplete Block Designs with Few Replicates

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1981

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Morris

2012

Design and Analysis of Experiments

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Generalized Cyclic Incomplete Block Designs

Cited by 10 publications

References 11 publications

Hormonal responses to opioid receptor blockade: during rest and exercise in cold and hot environments

Hormonal responses to opioid receptor blockade: during rest and exercise in cold and hot environments

Nonresolvable Incomplete Block Designs with Few Replicates

Computer Experiments

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