Generalized anxiety disorder among adults with attention deficit hyperactivity disorder

Fuller‐Thomson, Esme; Carrique, Lauren; MacNeil, Andie

doi:10.1016/j.jad.2021.10.020

Cited by 2 publications

(3 citation statements)

References 67 publications

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“…For example, nearly two-thirds of individuals with anxiety disorders also have concurrent depressive disorders and vice versa (6). Anxiety disorders are also common in individuals with bipolar disorder (BIP) (7, 8), schizophrenia (SCZ) (9), and attention deficit hyperactivity disorder (ADHD) (10, 11). Further, symptoms of anxiety (ANX), not meeting the criteria for anxiety disorder, frequently co-occur with other psychiatric disorders (12, 13).…”

Section: Introductionmentioning

confidence: 99%

“…6 Anxiety disorders are also common in individuals with bipolar disorder (BIP), 7, 8 schizophrenia (SCZ), 9 and attention deficit hyperactivity disorder (ADHD). 10, 11 Further, symptoms of anxiety (ANX), not meeting the criteria for anxiety disorder, frequently co-occur with other psychiatric disorders. 12, 13 Anxiety disorders and ANX co-occurring with psychiatric disorders have been linked with greater symptom burden, poorer course and outcome, and lower quality of life.…”

Section: Introductionmentioning

confidence: 99%

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Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders

Tesfaye,

Jaholkowski,

Shadrin

et al. 2023

Preprint

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BackgroundAnxiety disorders are prevalent and anxiety symptoms often co-occur with psychiatric disorders. Here, we aimed to identify genomic risk loci associated with anxiety, characterize its genetic architecture, and genetic overlap with psychiatric disorders.MethodsWe used the largest available GWAS of anxiety (GAD-2 score), schizophrenia, bipolar disorder, major depression, and attention deficit hyperactivity disorder (ADHD). We employed MiXeR and LAVA to characterize the genetic architecture and genetic overlap between the phenotypes. Additionally, conditional and conjunctional false discovery rate analyses were performed to boost the identification of genomic loci associated with anxiety and those shared with psychiatric disorders. Gene annotation and gene set analyses were carried out using OpenTargets and FUMA, respectively.ResultsAnxiety was polygenic with 8.4k estimated genetic risk variants and overlapped extensively with psychiatric disorders (4.1-7.8k variants). Both MiXeR and LAVA revealed predominantly positive genetic correlations between anxiety and psychiatric disorders. We identified 154 anxiety loci (139 novel) by conditioning on the psychiatric disorders. We identified loci shared between anxiety and major depression (n= 66), bipolar disorder (n= 19), schizophrenia (n= 51), and ADHD (n= 37). Genes annotated to anxiety loci exhibit enrichment for a broader range of biological pathways and differential tissue expression in more diverse tissues than those annotated to the shared loci.ConclusionsAnxiety is a highly polygenic phenotype with extensive genetic overlap with psychiatric disorders. These genetic overlaps enabled the identification of novel loci for anxiety and shared loci with psychiatric disorders. The shared genetic architecture may underlie the comorbidity of anxiety, and the identified genetic loci implicate molecular pathways that could become potential drug targets.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders

Tesfaye,

Jaholkowski,

Shadrin

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Attention-deficit/hyperactivity disorder (ADHD) is a common, chronic neurodevelopmental disorder defined as a persistent, transsituational pattern of inattention and/or hyperactivity-impulsivity inappropriate to the developmental stage (1), which affects approximately 4.4-5.2% of adults between 18 and 44 years of age (2,3). Adults with ADHD may struggle with emotional problems due to the existence of emotional dysregulation (4), risking the occurrence of comorbidities such as bipolar disorder (5), depression (6), anxiety (7,8), substance abuse (9,10), addictive behaviors (11,12), and personality disorders (13,14). Meanwhile, ADHD patients have a burden on their physical health and academic, social, and occupational functioning (15,16), and more deficits in quality of life (QoL) over their lifespan (17).…”

Section: Introductionmentioning

confidence: 99%

Bidirectional associations between maladaptive cognitions and emotional symptoms, and their mediating role on the quality of life in adults with ADHD: a mediation model

Pan,

Zhang,

Chen

et al. 2023

Front. Psychiatry

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Background/objectivesAdults with attention-deficit/hyperactivity disorder (ADHD) have more maladaptive cognitions, emotional problems and a poorer quality of life (QoL). A verification of the psychological model in clinical samples is needed for a better understanding of the mechanisms of ADHD diagnosis on QoL via maladaptive cognitions, emotional symptoms, and their interactions.Methods299 ADHD participants and 122 healthy controls were recruited. ADHD core symptoms, maladaptive cognitions, emotional symptoms and psychological QoL were rated. Pearson’s correlation and structural equation modeling were analyzed to explore the relationship and influence of ADHD diagnosis on QoL.ResultsMore maladaptive cognitions, emotional symptoms, and poorer QoL were found in the ADHD group, and the dysfunctional attitudes were on par between ADHD with or without medication (p = 0.368). Moderate to strong correlations were found between emotional symptoms, maladaptive cognitions and QoL, and ADHD core symptoms presented correlations among the above scores (r = 0.157 ~ 0.416, p < 0.01) in ADHD participants. The influence of ADHD diagnosis on QoL was mediated through maladaptive cognitions, emotional symptoms, and their bidirectional interactions (p < 0.05), especially those with stable medication.ConclusionOur study is the first to verify the psychological model in adults with ADHD in China. The findings determined the direct influence of ADHD diagnosis on QoL and the indirect influence through maladaptive cognitions, emotional symptoms, and their interactions, emphasizing the importance of interventions for emotional symptoms and maladaptive cognitions for ADHD patients both with or without medication for a better QoL outcome.

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Generalized anxiety disorder among adults with attention deficit hyperactivity disorder

Cited by 2 publications

References 67 publications

Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders

Identification of Novel Genomic Loci for Anxiety and Extensive Genetic Overlap with Psychiatric Disorders

Bidirectional associations between maladaptive cognitions and emotional symptoms, and their mediating role on the quality of life in adults with ADHD: a mediation model

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