Generalizability of splint therapy for temporomandibular joint disorders in the era of precision medicine

Effect of metabolic syndrome and obesity on the progression of knee osteoarthritis

“…Occupational physical activity is an important risk factor for knee OA, which may be affected by the characteristics of residential areas in which the participants lived in 3‐5 . As two‐thirds of the participants in this study lived in rural areas, the homogeneity of lifestyle may lead to potential selection bias.…”

“…2 That said, some points are worthy of further discussion.Occupational physical activity is an important risk factor for knee OA, which may be affected by the characteristics of residential areas in which the participants lived in. [3][4][5] As two-thirds of the participants in this study lived in rural areas, the homogeneity of lifestyle may lead to potential selection bias. Therefore, recommendations for future studies would include sensitivity analyses that determine whether characteristics of residential areas including walkability would affect the progression of knee OA.…”

“…Additionally, the generalizability of the study could be reached through including participants in other cities to enlarge the sample pool and balance the ratio of participants between urban and rural areas. Moreover, it would be interesting to explore whether findings in this study on knee OA may be generalized into other large‐joint OA, including hip OA, and other OA‐involve joints, such as hand OA or temporomandibular joint OA 5 …”