Generalizability of Clinical Trial Results for Bipolar Disorder to Community Samples

Hoertel, Nicolas; Strat, Yann Le; Lavaud, Pierre; Dubertret, Caroline; Limosin, Frédéric

doi:10.4088/jcp.12m07935

Cited by 51 publications

(23 citation statements)

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“…As previously suggested, MDD plus subthreshold hypomania is associated with increased risk for suicide (Angst et al, 2003;Judd and Akiskal, 2003) as well as a greater conversion rate to threshold-level bipolar disorder (Fiedorowicz et al, 2011;Zimmermann et al, 2009). However, results from two large, nationally representative studies reveal a strikingly high prevalence of bipolar disorders in emerging adulthood that appear to resolve substantially during the latter half of the third decade of life (Cicero et al, 2009;Hoertel et al, 2013a). In our study, prevalence rates of suicide attempt was significantly higher in individuals with lifetime D(m) (13.55% vs. 7.72%;OR¼1.87,], po0.001) and non-hierarchical D(m) (13.77% vs. 7.72%;OR¼1.91,], po0.001), compared with those with lifetime pure MDD and non-hierarchical pure MDD respectively.…”

Section: Discussionmentioning

confidence: 92%

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Why does the lifetime prevalence of major depressive disorder in the elderly appear to be lower than in younger adults? Results from a national representative sample

Hoertel

Strat

Gorwood

et al. 2013

Journal of Affective Disorders

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Section: Discussionmentioning

confidence: 92%

“…Third, severity and clinical significance of major depressive disorder are determined by the AUDADIS-IV at the syndromal rather than symptom level (Hoertel et al, 2013a).…”

Section: Discussionmentioning

confidence: 99%

Why does the lifetime prevalence of major depressive disorder in the elderly appear to be lower than in younger adults? Results from a national representative sample

Hoertel

Strat

Gorwood

et al. 2013

Journal of Affective Disorders

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“…They include severity of major depression (Sargeant et al, 1990; Skodol et al, 2011; Spijker et al, 2010; Steinert et al, 2014), number of lifetime MDEs (Skodol et al, 2011; Spijker et al, 2010, Steinert et al, 2014), co-occurring Axis I (Hoertel et al, 2013a, 2013b, 2013c; Keller et al, 1982, 1992; Klein et al, 2006; Manetti et al, 2014; Steinert et al, 2014) and Axis II disorders (Grilo et al, 2005; Skodol et al, 2011), history of suicide attempts (Avery and Winokur, 1978), family history of depression (Patten et al, 2010), concurrent physical health problems and psychosocial difficulties (Lam et al, 2009), early age at onset of first MDE (Hoertel et al, 2013a; Klein et al, 1999), stressful live events (Wang et al, 2012), female gender, older age and being divorced or widowed (Colman et al, 2011; Dowrick et al, 2011; Fava et al, 2007; Gilman et al, 2013; Hardeveld et al, 2013a, 2013b; Kornstein et al, 2000; Lam et al, 2009; Patten et al, 2012; ten Doesschate et al, 2010; Wang et al, 2012). …”

Section: Introductionmentioning

confidence: 99%

A comprehensive model of predictors of persistence and recurrence in adults with major depression: Results from a national 3-year prospective study

Hoertel

Blanco

Oquendo

et al. 2017

Journal of Psychiatric Research

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Identifying predictors of persistence and recurrence of depression in individuals with a major depressive episode (MDE) poses a critical challenge for clinicians and researchers. We develop using a nationally representative sample, the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC; N=34,653), a comprehensive model of the 3-year risk of persistence and recurrence in individuals with MDE at baseline. We used structural equation modeling to examine simultaneously the effects of four broad groups of clinical factors on the risk of MDE persistence and recurrence: 1) severity of depressive illness, 2) severity of mental and physical comorbidity, 3) sociodemographic characteristics and 4) treatment-seeking behavior. Approximately 16% and 21% of the 2,587 participants with an MDE at baseline had a persistent MDE and a new MDE during the 3-year follow-up period, respectively. Most independent predictors were common for both persistence and recurrence and included markers for the severity of the depressive illness at baseline (as measured by higher levels on the general depressive symptom dimension, lower mental component summary scores, prior suicide attempts, younger age at onset of depression and greater number of MDEs), the severity of comorbidities (as measured by higher levels on dimensions of psychopathology and lower physical component summary scores) and a failure to seek treatment for MDE at baseline. This population-based model highlights strategies that may improve the course of MDE, including the need to develop interventions that target multiple psychiatric disorders and promotion of treatment seeking to increase access to timely mental health care.

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“…Only one study, conducted in a clinical sample, [8] controlled for overall depression severity between groups, but its results may not be applicable to women in the general population. [35, 36] …”

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confidence: 99%

Are Symptom Features of Depression During Pregnancy, the Postpartum Period and Outside the Peripartum Period Distinct? Results From a Nationally Representative Sample Using Item Response Theory (Irt)

et al. 2014

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Background Whether there are systematic differences in depression symptom expression during pregnancy, the postpartum period and outside these periods (i.e., outside the peripartum period) remains debated. The aim of this study was to use methods based on item response theory (IRT) to examine, after equating for depression severity, differences in the likelihood of reporting DSM-IV symptoms of major depressive episode (MDE) in women of childbearing age (i.e., aged 18-50) during pregnancy, the postpartum period and outside the peripartum period. Method We conducted these analyses using a large, nationally representative sample of women of childbearing age from the USA (n = 11,256) who participated in the second wave of the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC). Results The overall 12-month prevalence of all depressive criteria (except for worthlessness/guilt) was significantly lower in pregnant women than in women of childbearing age outside the peripartum period, whereas the prevalence of all symptoms (except for “psychomotor symptoms”) were not significantly different between the postpartum and the non-peripartum group. There were no clinically significant differences in the endorsement rates of symptoms of MDE by pregnancy status when equating for levels of depression severity. Conclusions This study suggests that the clinical presentation of depressive symptoms in women of childbearing age does not differ during pregnancy, the postpartum period and outside the peripartum period. These findings do not provide psychometric support for the inclusion of the peripartum onset specifier for major depressive disorder in the DSM-5.

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Generalizability of Clinical Trial Results for Bipolar Disorder to Community Samples

Cited by 51 publications

References 0 publications

Why does the lifetime prevalence of major depressive disorder in the elderly appear to be lower than in younger adults? Results from a national representative sample

Why does the lifetime prevalence of major depressive disorder in the elderly appear to be lower than in younger adults? Results from a national representative sample

A comprehensive model of predictors of persistence and recurrence in adults with major depression: Results from a national 3-year prospective study

Are Symptom Features of Depression During Pregnancy, the Postpartum Period and Outside the Peripartum Period Distinct? Results From a Nationally Representative Sample Using Item Response Theory (Irt)

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