Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population

Glans, Martin; Bejerot, Susanne; Humble, Mats B.

doi:10.1192/bjpo.bp.116.004325

Cited by 15 publications

(10 citation statements)

References 33 publications

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“…In our study the 5PQ assigned 38.2% of the females and 19.3% of the males as GJH. This is similar to the prevalence rates reported in a large (n = 1039) Swedish study [13] also using the Swedish 5PQ as an assessment method for GJH. One study of female twins in the UK [5] reported the prevalence rate of GJH to be around 20%, although participants aged 20-30 years (similar age to our participants) had a prevalence rate (34%), closer to our findings.…”

Section: Prevalence Rates Of Gjh In Our Studysupporting

confidence: 88%

Self-rated joint hypermobility: the five-part questionnaire evaluated in a Swedish non-clinical adult population

Glans

Humble

Elwin

et al. 2020

BMC Musculoskelet Disord

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Background: The conventional way to identify generalised joint hypermobility is by a physical examination according to the Beighton Score. However, a physical examination is time-consuming in clinical practise and may be unfeasible in population-based studies. The self-assessment five-part questionnaire on hypermobility (5PQ) offers a more practicable way to identify GJH. The aim of this study was to test validity and reliability of the five-part questionnaire on hypermobility (5PQ) translated into Swedish on a non-clinical adult population. Methods: A structured procedure was used for the translation of the 5PQ into Swedish. The Beighton Score was used as reference standard for generalised joint hypermobility. Test-retest reliability was tested in a separate group who filled in the questionnaire twice with a ten-week interval. Participants consisted of a convenience sample recruited in Stockholm, Sweden (2017). Results: A total of 328 participants were included in the study, 297 participants in the validity group and 31 participants in the reliability group. When evaluated against a present Beighton Score with an age-dependent cutoff, the Swedish 5PQ attained a sensitivity of 91%, a specificity of 75% and an area under the curve of 0.87. The Swedish 5PQ showed substantial to almost perfect test-retest reliability. Conclusions: The Swedish 5PQ is a valid and reliable instrument to screen for or to identify generalised joint hypermobility.

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Section: Prevalence Rates Of Gjh In Our Studysupporting

confidence: 88%

Self-rated joint hypermobility: the five-part questionnaire evaluated in a Swedish non-clinical adult population

Glans

Humble

Elwin

et al. 2020

BMC Musculoskelet Disord

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“…Results showed that the rate of JH and autonomic symptoms were significantly higher among people with neurodevelopmental disorders than in the control group. More recently, Glans et al (31) explored the potential association between JH and autistic traits in the general population. One thousand thirty-nine Swedish adults responded to the Five-point questionnaire for JH (32), and others instruments assessing neurodevelopmental traits including the abridged version of the 50-item Autism Spectrum Quotient (33).…”

Section: Autism Joint Hypermobility (Jh) and Hypermobility-related Dmentioning

confidence: 99%

Autism, Joint Hypermobility-Related Disorders and Pain

et al. 2018

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Autism Spectrum Disorder (ASD) and Joint Hypermobility-Related Disorders are blanket terms for two etiologically and clinically heterogeneous groups of pathologies that usually appears in childhood. These conditions are seen by different medical fields, such as psychiatry in the case of ASD, and musculoskeletal disciplines and genetics in the case of hypermobility-related disorders. Thus, a link between them is rarely established in clinical setting, despite a scarce but growing body of research suggesting that both conditions co-occur more often than expected by chance. Hypermobility is a frequent sign of hereditary disorders of connective tissue (e.g., Ehlers-Danlos syndromes, Marfan syndrome), in which the main characteristic is the multisystem fragility that prone to proprioceptive and motor coordination dysfunction and hence to trauma and chronic pain. Considering the high probability that pain remains disregarded and untreated in people with ASD due to communication and methodological difficulties, increasing awareness about the interconnection between ASD and hypermobility-related disorders is relevant, since it may help identify those ASD patients susceptible to chronic pain.

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“…Nevertheless, these two clinical entities retain their association through into adulthood[ 26 , 36 ]. Interestingly, however, subclinical expression of neurodevelopmental (ADHD, ASD or DCD) traits in the general population are not strongly associated with hypermobility, suggesting that the expression of this association is limited to clinical populations[ 37 ].…”

Section: Resultsmentioning

confidence: 99%

Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression

Sharp¹,

Critchley²,

Eccles³

2021

WJP

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The mind is embodied; thoughts and feelings interact with states of physiological arousal and physical integrity of the body. In this context, there is mounting evidence for an association between psychiatric presentations and the expression variant connective tissue, commonly recognised as joint hypermobility. Joint hypermobility is common, frequently under-recognised, significantly impacts quality of life, and can exist in isolation or as the hallmark of hypermobility spectrum disorders (encompassing joint hypermobility syndrome and hypermobile Ehlers-Danlos syndrome). In this narrative review, we appraise the current evidence linking psychiatric disorders across the lifespan, beginning with the relatively well-established connection with anxiety, to hypermobility. We next consider emerging associations with affective illnesses, eating disorders, alongside less well researched links with personality disorders, substance misuse and psychosis. We then review related findings relevant to neurodevelopmental disorders and stress-sensitive medical conditions. With growing understanding of mind-body interactions, we discuss potential aetiopathogenetic contributions of dysautonomia, aberrant interoceptive processing, immune dysregulation and proprioceptive impairments in the context of psychosocial stressors and genetic predisposition. We examine clinical implications of these evolving findings, calling for increased awareness amongst healthcare professionals of the transdiagnostic nature of hypermobility and related disorders. A role for early screening and detection of hypermobility in those presenting with mental health and somatic symptoms is further highlighted, with a view to facilitate preventative approaches alongside longer-term holistic management strategies. Finally, suggestions are offered for directions of future scientific exploration which may be key to further delineating fundamental mind-body-brain interactions.

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Generalised joint hypermobility and neurodevelopmental traits in a non-clinical adult population

Cited by 15 publications

References 33 publications

Self-rated joint hypermobility: the five-part questionnaire evaluated in a Swedish non-clinical adult population

Self-rated joint hypermobility: the five-part questionnaire evaluated in a Swedish non-clinical adult population

Autism, Joint Hypermobility-Related Disorders and Pain

Connecting brain and body: Transdiagnostic relevance of connective tissue variants to neuropsychiatric symptom expression

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