General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state

Goto, Yukinobu; Ho, Shinn‐Ying; McAdoo, John; Fanning, N. F.; Wang, J.; Redmond, H. P.; Shorten, George

doi:10.1046/j.1365-2346.2000.00708.x

Cited by 23 publications

(10 citation statements)

References 15 publications

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“…Contradictory results also suggest a different role, as demonstrated in the present study, for sevoflurane and support a more anti-inflammatory pronounced impact of this substance. Whereas inhalational anesthetics such as halothane and nitrous oxide induced peripheral lymphocytopenia in patients undergoing elective hysterectomy, sevoflurane exposure had the opposite effect (31,32) or did not influence lymphocyte apoptosis (33). If this is so, then the clinical impact is of interest and should be investigated in further clinical studies.…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Boost

Leipold²,

Scheiermann³

et al. 2009

Int J Mol Med

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Abstract. The nuclear factor (NF)-κB/inhibitory (I)κB· pathway is one of the most important intracellular signal transduction pathways during inflammation which is induced by a variety of major early response cytokines. Recent studies suggest that volatile anesthetics interfere with inflammatory cytokine production through inhibition of intracellular signal transduction pathways. We, therefore, aimed to investigate the effects of the volatile anesthetics sevoflurane and isoflurane on NF-κB/IκB·-dependent intracellular signal transduction in human monocytic THP-1 cells induced by tumor necrosis factor-· (TNF-·) and production of interleukin-8 (IL-8) and downstream heme oxygenase-1 (HO-1). THP-1 cells, a human monocytic cell line, were used in an in vitro model which enables the exposure to volatile anesthetics. Using this model, THP-1 cells were subjected to sevoflurane or isoflurane exposure (1 MAC each) and were stimulated with TNF-· (50 or 100 ng/ml). Compared to untreated cells, expression of intracellular HO-1-protein and release of IL-8 into cell culture supernatants and corresponding mRNA expression were attenuated in THP-1 cells exposed to sevoflurane and isoflurane, respectively. Moreover, translocation of NF-κB and degradation of IκB· were markedly reduced by both anesthetics. Notably, under unstimulated conditions, exposure to sevoflurane induced a sustained upregulation of the IκB· content in THP-1 cells. We demonstrated inhibition of TNF-·-induced gene expression and release of IL-8 and HO-1 in human monocytic THP-1 cells exposed to both volatile anesthetics. This was associated with an upregulated intracellular IκB· content followed by decreased NF-κB translocation. This was more sustained during exposure to sevoflurane and may provide an additional intracellular mechanism for the anti-inflammatory effects associated with sevoflurane administration.

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Section: Discussionmentioning

confidence: 99%

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Boost

Leipold²,

Scheiermann³

et al. 2009

Int J Mol Med

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“…3 of infections after joint arthroplasty occur during the first 3 months after surgery [15]. If detected early and treated aggressively, there is a better chance of eradicating the infection [31].…”

Section: Discussionmentioning

confidence: 99%

Circulating Cytokines after Hip and Knee Arthroplasty: A Preliminary Study

Shah

Aslam

Patil

et al. 2008

Clin Orthop Relat Res

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“…Sevoflurane is an inhalational anesthetic that is widely used in clinical practice. Goto et al (27) showed that sevoflurane had no influence on neutrophil apoptosis, nor on IL-6 or IL-8 concentrations. Furthermore, El Azab et al (28) showed that sevoflurane did not significantly affect inflammatory cells.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits

Wang

Cang

Zhao

2016

Experimental and Therapeutic Medicine

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Abstract. The mechanism underlying the effect of thoracic epidural anesthesia (TEA) on hypoxia-induced acute lung injury (ALI) is currently unknown. In the present study, a rabbit acute lung injury model was established to investigate the effects of TEA on inflammatory factors, pulmonary surfactant and ultrastructure. A total of 56 rabbits were randomly assigned to four groups (n=14 per group): Control group (Group C), hypoxia group (Group H), sevoflurane group (Group S) and combined sevoflurane-epidural anesthesia group (Group ES). The ALI model was considered to have been successfully induced when the ratio of arterial oxygen partial pressure to fractional inspired oxygen was <300. The correct placement of a catheter for TEA was confirmed using epidurography. ALI was maintained for 3 h. Arterial blood samples were collected from all groups during spontaneous breathing (T 0 ) and at 3 h after ALI induction (T 5 ) in order to evaluate the serum levels of interleukin (IL)-6, IL-8 and IL-10. Bronchoalveolar lavage fluid was harvested to determine the total phospholipid, saturated phosphatidylcholine and total protein levels. Furthermore, the dry/wet weight ratio and the mRNA expression levels of IL-6, IL-8 and IL-10 in the lung tissue were determined using ELISA. In addition, light and transmission electron microscopy and histological techniques were used to examine the morphology of alveolar type II cells in the rat lung tissue. The results indicate that changes of serum IL-6, IL-8 and IL-10 levels following ALI were consistent with the changes in the mRNA expression levels of IL-6, IL-8 and IL-10 in the lung tissue. TEA attenuated these changes and thus reduced the severity of the ALI. In addition, TEA improved the alveolar structure, reduced the number of polymorphonuclear cells and mitigated the damage of lamellar bodies. In summary, the results of the present study indicate that TEA reduces lung tissue damage by inhibiting systemic and local inflammation, decreasing the inactivation of pulmonary surfactant and improving the alveolar ultrastructure following ALI.

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General versus regional anaesthesia for cataract surgery: effects on neutrophil apoptosis and the postoperative pro-inflammatory state

Cited by 23 publications

References 15 publications

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Sevoflurane and isoflurane decrease TNF-α-induced gene expression in human monocytic THP-1 cells: Potential role of intracellular IκBα regulation

Circulating Cytokines after Hip and Knee Arthroplasty: A Preliminary Study

Protective effects of thoracic epidural anesthesia on hypoxia-induced acute lung injury in rabbits

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