The development of a sustainable general thoracic surgery program in low-and middle-income countries (LMICs) requires closely coordinated multidisciplinary capacity building. Human and material resources for case finding and work up (radiology), intraoperative care (anesthesia), and postoperative management (critical care, pathology, oncology) are necessary to facilitate care of patients with general thoracic disorders. Here we review (1) the epidemiology of thoracic diseases treated with surgery, (2) barriers and solutions to capacity building, and (3) several examples of successful surgical programs that have served to not only provide general thoracic capacity but also strengthen the local health system overall.