General Systemic States

The effects of anaesthesia on cell death in a porcine model of neonatal hypoxic-ischaemic brain injury

“… 10 Although the translatability of hypoxic-ischaemic hypothermia experiments in rodents is limited, it is noteworthy that loss of neuroprotection has not been reported in awake and unsedated postnatal day 7 rats or postnatal day 17 ferrets. 31 , 32 This disparity may be attributed to physiological differences in heat-conserving thermoregulation, 33 experimental differences in insult protocol, or both.…”