General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics

H, Yan; Zhao, Lingyun; Shang, Wenting; Liu, Zhongqun; Xie, Wensheng; Cai, Qiang; Xiong, Zhiyuan; Zhang, Ranran; Li, Baohua; Sun, Xiaodan; Kang, Feiyu

doi:10.1007/s12274-016-1330-4

Cited by 29 publications

(24 citation statements)

References 44 publications

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“…An in-situ surface polymerization was developed to coat magnetite NPs with polypyrrole as well as poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate; PEDOT:PSS; Yan et al, 2017 ). A conjugated polymer here allows for NIR absorbance.…”

Section: Polymeric Componentmentioning

confidence: 99%

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

2020

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Theranostics is a fast-growing field due to demands for new, efficient therapeutics which could be precisely delivered to the target site using multimodal imaging with enhancing auxiliary actions. In this review article we discuss theranostic nanoplatforms containing polymers and magnetic nanoparticles along with other components. Magnetic nanoparticles allow for both diagnostic and therapeutic (hyperthermia) capabilities, while polymers can be reservoirs for drugs and are easily functionalized for cell targeting. We focus on the most important design strategies to achieve optimal theranostic effects as well as the roles of different components included in theranostics, reviewing the literature from the last 5 years.

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Section: Polymeric Componentmentioning

confidence: 99%

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

2020

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“…Besides, excellent therapeutic efficacy was acquired by intravenous injection of PEDOT:PSS‐PEG in mice. Since then, a series of PTT agents based on PEDOT:PSS were further developed by functional modification or incorporation with other materials …”

Section: Cps For Pttmentioning

confidence: 99%

Conjugated Polymer Materials for Photothermal Therapy

Sun

Liu

et al. 2018

Advanced Therapeutics

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Although many approaches including operative treatment, chemotherapy, and radiotherapy have been developed to struggle against cancer, they are still insufficient in clinical application owing to the non-ideal therapeutic efficiency and serious side effects. Photothermal therapy (PTT) is emerging as a novel alternative to the conventional therapies because of minimal invasiveness and high specificity. Conjugated polymers (CPs) with the merits of unique optical properties and biological activities have been extensively investigated as functional photothermal conversion materials. The critical design strategies of CPs with high photothermal conversion efficiency and excellent PTT effect are reviewed in this progress report. The major challenges and future development of CPs for PTT are also discussed.

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“…These properties make Fe 3 O 4 NPs valuable agents in medical applications. [21][22][23][24][25][26] Specifically designed core-shell nanocomposites are widely used in the fields of biosensors, catalysts, and energy storage systems. Generally, metals and metal oxides, like Fe 3 O 4 are preferred to use in core covered by a thin polymeric structure to protect the core and increase stability and biosafety.…”

Section: Introductionmentioning

confidence: 99%

“…[27][28][29][30] Magnetic Fe 3 O 4 and NIR-absorbing conductive polymer PPy in core-shell structure received significant attention for PTT. [26,[31][32][33][34][35] Herein, it is aimed to obtain Fe 3 O 4 @PPy in core-shell structure that has excellent dispersibility in aqueous media, superior photothermal performance, high photothermal conversion efficiency, and stability with strong magnetic properties. For the first time we developed a facile two-step modified procedure, co-precipitation of ferric and ferrous chloride in alkaline media to prepare Fe 3 O 4 NPs, and in situ polymerization of pyrrole on the surface of Fe 3 O 4 NPs core using PVA as a stabilizer and SDBS as emulsifier agent, towards PTT application for the synthesis of the binary Fe 3 O 4 @PPy nanocomposite having core-shell structure.…”

Section: Introductionmentioning

confidence: 99%

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NIR‐responsive Fe₃O₄@PPy nanocomposite for efficient potential use in photothermal therapy

Getiren

Çıplak

Gökalp

et al. 2020

J of Applied Polymer Sci

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In this work, superparamagnetic Fe3O4@PPy nanocomposite with core‐shell structure having strong near‐infrared (NIR) absorption is synthesized via a facile two‐step modified procedure. The prepared nanocomposite samples are characterized by UV–vis, FTIR, SEM, TEM, VSM, and XRD. The effects of laser power density (1.5–2.5 W cm−2) and aqueous concentration (0.01–0.2 mg ml−1) of the nanocomposite on the photothermal performance are investigated in the NIR region (808 nm). At 0.1 mg ml−1 concentration, the temperature reaches up to 50.1°C, 64.1°C, and 78.4°C within 10 min, under 1.5 W cm−2, 2.0 W cm−2, and 2.5 W cm−2 NIR laser power density values, respectively. Photothermal conservation efficiency is calculated as 43.9% and the nanocomposite exhibits excellent photothermal stability. In summary, the core‐shell Fe3O4@PPy nanocomposite is a promising candidate for photothermal therapy and simultaneous magnetic field‐guided treatments.

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General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics

Cited by 29 publications

References 44 publications

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

Conjugated Polymer Materials for Photothermal Therapy

NIR‐responsive Fe₃O₄@PPy nanocomposite for efficient potential use in photothermal therapy

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General synthesis of high-performing magneto-conjugated polymer core–shell nanoparticles for multifunctional theranostics

Cited by 29 publications

References 44 publications

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

Theranostics Based on Magnetic Nanoparticles and Polymers: Intelligent Design for Efficient Diagnostics and Therapy

Conjugated Polymer Materials for Photothermal Therapy

NIR‐responsive Fe3O4@PPy nanocomposite for efficient potential use in photothermal therapy

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Product

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NIR‐responsive Fe₃O₄@PPy nanocomposite for efficient potential use in photothermal therapy