General Principles and Limitations for Detection of RNA Modifications by Sequencing
Yuri Motorin,
Mark Helm
Abstract:Metrics & MoreArticle Recommendations * sı Supporting Information CONSPECTUS: Among the many analytical methods applied to RNA modifications, a particularly pronounced surge has occurred in the past decade in the field of modification mapping. The occurrence of modifications such as m 6 A in mRNA, albeit known since the 1980s, became amenable to transcriptome-wide analyses through the advent of next-generation sequencing techniques in a rather sudden manner. The term "mapping" here refers to detection of RNA m… Show more
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